Impact of Perioperative Body Composition Abnormalities on Patient Outcomes After Liver Transplantation

N/ACompletedNCT06209775

Zhejiang University996 enrolled

Overview

Accumulating evidence suggests the prognostic significance of body composition in chronic diseases and neoplastic diseases. CT imaging-based body composition abnormalities are significantly associated with post-LT adverse outcomes including decreased quality of life (QOL), impaired graft regeneration and mortality. However, the perioperative changes in body composition and their potential clinical implications remain unexplored. The objective of this study is to systematically explore and clarify the correlation between body composition and the prognosis of liver transplant patients through dynamic peri-transplant mornitoring.

Study Type

OBSERVATIONAL

Enrollment

996

Conditions

Liver Transplantation Body Composition

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients undergoing deceased donor liver transplantation (DDLT) for the first time. Exclusion Criteria: * Pediatric transplants * Re-transplants * Multi-organ transplants * Liver cancer patients with macrovascular invasion or distant metastasis * Patients who died within 30 days after transplantation

Outcomes

Primary Outcomes

Postoperative mortality

Time frame: 2015.1.1-2022.12.31