Patients meeting enrollment criteria will be randomized 1:1 to either the dobutamine or the control group. In the dobutamine group, 3\~6μg/kg/min dobutamine will be injected intravenously after anesthesia induction until hemostasis is completed. To ensure preload, transesophageal echocardiography (TEE) will be used to monitor left ventricular end-diastolic volume (LVEDV) and stroke volume (SV). In the control group, 3mL/h normal saline will be injected intravenously after anesthesia induction until hemostasis is completed, and the liquid will be restricted according to the currently commonly used principle of low central venous pressure(LCVP), nitroglycerin can be used if necessary.
Patients meeting enrollment criteria will be randomized 1:1 to either the dobutamine or the control group. Dobutamine group: 3\~6μg/kg/min dobutamine will be injected intravenously after anesthesia induction until hemostasis is completed. The dose of dobutamine will be increased if the operating field grade exceeds Grade II. Monitoring LVEDV and SV with TEE to ensure preload: after admission, the patient will be given 3-4 mL /kg/h equilibrium fluid as background infusion. LVEDV and SV will be monitored using TEE every 30 minutes after anesthesia induction. If LVEDV\<75mL or SV\<45mL, 200mL colloidal fluid will be given within 5min. Control group: 3mL/h normal saline will be injected intravenously after anesthesia induction until hemostasis is completed. According to the currently commonly used principle of LCVP, the fluid will be limited to 3-4 mL/kg/h after anesthesia induction. If the operating field grade exceeds Grade II, nitroglycerin will be injected intravenously for remedial purposes at a rate of 0.3-0.8μg/kg/min. Dobutamine and nitroglycerin will be stopped after hemostasis, and the anesthesiologist will supplement the infusion according to his/her experience.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Enrollment
51
In the dobutamine group, 3\~6μg/kg/min dobutamine will be injected intravenously after anesthesia induction until hemostasis is completed. The dose of dobutamine will be increased if the operating field grade exceeds Grade II. Monitoring LVEDV and SV with TEE to ensure preload: after admission, the patient will be given 3-4 mL /kg/h equilibrium fluid as background infusion. LVEDV and SV will be monitored using TEE every 30 minutes after anesthesia induction. If LVEDV\<75mL or SV\<45mL, 200mL colloidal fluid will be given within 5min.
In the control group, 3mL/h normal saline will be injected intravenously after anesthesia induction until hemostasis is completed. According to the currently commonly used principle of LCVP, the fluid will be limited to 3-4 ml /kg/h after anesthesia induction. If the operating field grade exceeds Grade II, nitroglycerin will be injected intravenously for remedial purposes at a rate of 0.3-0.8μg/kg/min.
West China Hospital
Chengdu, Sichuan, China
Variation of hepatic venous blood flow spectrum
The method of TEE monitoring hepatic vein blood flow: The TEE probe will be inserted into the patient's esophagus near the gastric fundus to show the liver. Next the probe will be rotated to the right to show the short axis of the inferior vena cava and the hepatic vein. Then the probe angle will be adjusted to 30-40° to show the long axis of the inferior vena cava and the hepatic vein, and the junction of the inferior vena cava and the hepatic vein. To record the blood flow spectrum of the hepatic vein using pulsed Doppler ultrasound (PW mode), the sampling volume should be placed in the hepatic vein, approximately 1.5-2cm away from the inferior vena cava opening. The angle between the sound beam and the blood flow direction should be less than 30°. The blood flow spectrum variation refers to the spectrum change measured at each time point relative to the basic spectrum after anesthesia induction.
Time frame: Intraoperative (after anesthesia induction, 10 minutes after the administration of dobutamine/normal saline, after pneumoperitoneum is established, and after hemostasis is completed.)
Intraoperative blood loss
Intraoperative blood loss can be calculated by adding the blood volume absorbed by gauze (8ml for small gauze, 25ml for medium gauze, and 50ml for large gauze) to the blood volume collected in the suction tank during the operation.
Time frame: intraoperative (Operation starts until hemostasis is completed.)
Surgical field grade
Grade Ⅰ is defined as the inferior vena cava and hepatic veins are very relaxed, and the liver section has little blood seepage, which is very easy to operate. Grade Ⅱ is defined as the inferior vena cava and hepatic vein are relaxed, and the liver section has less blood seepage, which is easy to operate. Grade Ⅲ is defined as the inferior vena cava and hepatic vein are tense, and the liver section oozes more blood, which is difficult to operate. Grade Ⅳ is defined as the inferior vena cava and hepatic vein are obviously tense, and the liver section oozes a lot of blood, which is very difficult to operate.
Time frame: Intraoperative (When the liver parenchyma is transected after the pringle maneuver.)
The remedy rate
During hepatic parenchyma dissection, if the operating field grade is greater than grade II, the dobutamine dose (3-6 μg/kg/min) will be increased in the dobutamine group, and nitroglycerin (0.3-0.8μg /kg/min) will be added in the control group.
Time frame: Intraoperative (The liver parenchyma is transected until hemostasis is completed.)
Duration of intraoperative hypotension
Intraoperative hypotension is defined as SBP\<90mmHg, or MAP\<60mmHg, or MAP/SBP decreasing greater than 20% of the baseline value during the perioperative period.
Time frame: Intraoperative (From anesthesia induction to the patient leaving the operating room.)
Ejection fraction
The ejection fraction will be measured by M-mode ultrasonography on the transgastric short-axis section of the left ventricle using TEE, recording the average value of three cardiac cycles.
Time frame: Intraoperative (anesthesia induction, 10 minutes after the administration of dobutamine/normal saline, after pneumoperitoneum is established, and after hemostasis is completed.)
The dose of vasoactive drugs
When perioperative SBP\<90mmHg or MAP\< 65mmHg, vasoactive drugs will be administered by the anesthesiologist.
Time frame: Intraoperative (From anesthesia induction to the patient leaving the operating room.)
Intraoperative urine volume
After anesthesia induction, all patients will undergo catheterization to record urine volume during the operation.
Time frame: Intraoperative (anesthesia induction to the patient leaving the operating room.)
Lactic acid
Invasive blood pressure will be monitored by the radial artery after anesthesia induction, and blood gas analysis will be performed after anesthesia induction and hepatic parenchyma dissection.
Time frame: Intraoperative (after anesthesia induction, liver parenchyma transection is completed.)
Length of operation
From the beginning to the end of the surgery.
Time frame: Intraoperative (From the beginning to the end of the surgery.)
Loss of hemoglobin
Preoperative hemoglobin content minus the hemoglobin content on the third day after surgery equals hemoglobin loss.
Time frame: Preoperative and the third day after surgery.
Loss of albumin
Preoperative albumin content minus the albumin content on the third day after surgery equals albumin loss.
Time frame: Preoperative and the third day after surgery.
Postoperative liver function (TB, ALT, AST) levels
The liver function (TB, ALT, AST) levels after surgery.
Time frame: The first and third day after surgery.
Incidence of AKI
AKI stage 1 is defined as serum creatinine(SCR) increases 1.5-2 times higher than the baseline. AKI stage 2 is defined as SCR is 2-3 times higher than the baseline. AKI stage 3 is defined as SCR increases by more than 3 times compared with the baseline.
Time frame: Within 3 days after surgery
Incidence of postoperative pulmonary complications
Pulmonary complications include pulmonary infection, respiratory failure, and moderate or large pleural effusion.
Time frame: Up to 7days after surgery.
Length of postoperative hospitalization
determined by the number of days from operation to discharge.
Time frame: Up to 2 weeks after surgery.
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