Cardiovascular And Metabolic Risk After Arthroplasty

Changes in low-molecular weight metabolites

Low-molecular weight metabolites are measured using Biocrates Absolute IDQ p180 kit (BIOCRATES Life Sciences AG, Innsbruck, Austria), which enables to quantify lipides, acylcarnitines, aminoacids, biogenic amines, polyamides

Time frame: 5 years

Oxidative stress index

Serum oxidative stress index. Expressed in %. The percentage of the ratio of total plasma peroxide concentration to plasma total antioxidative capacity (TAC, expressed in mmol trolox equivalent/L).

Time frame: 5 years

Leptin levels

Measured from serum. Expressed in ng/ml.

Time frame: 5 years

Metabolic syndrome risk score

A composite risk score is used to assess metabolic syndrome risk and include waist circumference(cm), HDL-cholesterol level(mmol/L), fasting glucose level(mmol/L), triglycerides level(mmol/L), blood pressure(mmHg). Each factor gives one point to the total score (range 0-5)

Time frame: 5 years

Harris Hip score or Hospital for Special Surgery Knee score

Harris Hip Score for hip arthroplasty patients. The HHS is divided into three sections. The first section are questions about pain and its impact which are answered by the patient or client. The second and third sections require specialist to assess the patient or client's hip joint and function. The HHS is a measure of dysfunction so the higher the score, the better the outcome for the individual. The maximum score possible is 100. Results can be interpreted with the following: \<70 = poor result; 70-80 = fair, 80-90 = good, and 90-100 = excellent.

Time frame: 5 years

Central systolic blood pressure

Central systolic blood pressure is measured using the Sphygmocor device. Expressed in mmHg.

Time frame: 5 years

Central diastolic blood pressure

Central diastolic blood pressure is measured using the Sphygmocor device. Expressed in mmHg.

Time frame: 5 years

Composite of cardiovascular clinical events

Composite of stroke, myocardial infarction, cardiovascular death, unstable angina

Time frame: 5 years

Oxidized LDL-cholesterol

Measured from serum. Expressed in mmol/L

Time frame: 5 years

Adiponectin level

Measured from serum, expressed in ng/ml

Time frame: 5 years

Augmentation index

Measured using the Sphygmocor device. The augmentation index (AI) is an indirect measure of arterial stiffness and increases with age, and it is calculated as AG (augmentation pressure) divided by PP(pulse pressure) ×100 to give a percentage.

Time frame: 5 years

SF-36

The Short Form (36) Health Survey is a 36-item, patient-reported survey of patient health. The SF-36 consists of eight scaled scores, which are the weighted sums of the questions in their section. Each scale is directly transformed into a 0-100 scale on the assumption that each question carries equal weight. The lower the score the more disability. The higher the score the less disability i.e., a score of zero is equivalent to maximum disability and a score of 100 is equivalent to no disability.

Time frame: 5 years

Hospital for Special Surgery knee score

The HSS Knee Score is based on a total of 100 points. The score is divided into seven categories, which include pain, function, range of motion, muscle strength, flexion deformity, instability, and subtractions. The knee is initially given a score of 0, and additions or subtractions are made according to specific criteria. The higher the score, the better the outcome. Approximately 50% of the score is based on a patient interview and the remaining on physical exam.

Time frame: 5 years

Central pulse pressure

Measured using the Sphygmocor device. Expressed in mmHg.

Time frame: 5 years