The aim of this randomized controlled trial was to compare the efficacy and cost-effectiveness of using progestin with GnRH antagonist to prevent premature LH surge in poor responders undergoing double stimulation protocol.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
120
HMG ( 300IU) was used during the follicular phase of ovarian stimulation (FPS) and during the luteal phase of ovarian stimulation (LPS). Progestin (dydrogesterone) 30 mg/day was used to prevent premature LH surge during the FPS and LPS.
HMG ( 300IU) was used during the follicular phase of ovarian stimulation (FPS) and during the luteal phase of ovarian stimulation (LPS). Flexible GnRH antagonist protocol (Cetrorelix acetate) (0.2 mg) was used to prevent premature LH surge during the FPS and LPS.
Bedaya Hospital
Giza, Egypt
Medications costs per retrieved oocyte
Total cost of medications used in all cycles/number of retrieved oocytes
Time frame: Ten to fifteen days after starting ovarian stimulation]
Clinical pregnancy rate
Presence of intrauterine gestational sac detected by transvaginal ultrasound
Time frame: 5 weeks after embryo transfer]
Ongoing Pregnancy Rate
Pregnancies continued beyond 20 weeks gestation
Time frame: 18 weeks after embryo transfer]
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