Longitudinal, observational cohort study to evaluate changes in left atrial (LA) reservoir function during exercise and overall exertional capacity in patients following catheter ablation for paroxysmal atrial fibrillation (AF).
EXCLAMATORY is a longitudinal observational cohort clinical research study to evaluate the effects of catheter ablation for paroxysmal atrial fibrillation on left atrial and left ventricular performance during exercise, as well as effects on overall exercise capacity
Study Type
OBSERVATIONAL
Enrollment
50
Complete the Self- Report Evaluation-Duke Activity Status Index
Complete the Self- Report Evaluation, Atrial Fibrillation Effect on Quality of Life Questionnaire
Cardiopulmonary exercise test (CPET)
Virginia Commonwealth University
Richmond, Virginia, United States
RECRUITINGChange in LA reservoir function reserve at submaximal exercise after catheter ablation in patients with paroxysmal AF.
Change in LA reservoir volume reserve from baseline to follow up, change in left ventricular (LV) stroke volume reserve from baseline to follow up, correlation between changes in LA reservoir volume reserve and changes in LV stroke volume reserve. Therefore the follow up testing will be performed 5-6 months (to be more specific: 150-180 days) after catheter ablation.
Time frame: Baseline and the follow up testing will be performed 5-6 months (to be more specific: 150-180 days) after catheter ablation.
Change in LV stroke volume reserve at submaximal exercise after catheter ablation in patients with paroxysmal AF.
Change in LA reservoir volume reserve from baseline to follow up, change in LV stroke volume reserve from baseline to follow up, correlation between changes in LA reservoir volume reserve and changes in LV stroke volume reserve.
Time frame: Baseline and the follow up testing will be performed 5-6 months (to be more specific: 150-180 days) after catheter ablation.
Correlation between changes in LA reservoir volume reserve and changes in LV stroke vol reserve after catheter ablation in patients with paroxysmal AF
Correlation between changes in LA reservoir volume reserve and changes in LV stroke volume reserve after catheter ablation in patients with paroxysmal AF
Time frame: Baseline and the follow up testing will be performed 5-6 months (to be more specific: 150-180 days) after catheter ablation.
Correlation between changes in LA reservoir function reserve at submaximal exercise and changes in mixed venous oxygen tension (pVO2) .
Correlation between changes in LA reservoir function reserve at submaximal exercise and changes in pVO2 after catheter ablation
Time frame: Baseline and the follow up testing will be performed 5-6 months (to be more specific: 150-180 days) after catheter ablation.
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Transthoracic echocardiogram at rest and immediately following peak exercise during CPET
Ambulatory cardiac rhythm assessment
Cardiovascular magnetic resonance (CMR) study at rest and during two stages of submaximal exercise (ExeCMR)
Correlation between changes in LV stroke volume reserve at submaximal exercise and changes in pVO2
Correlation between changes in LV stroke volume reserve at submaximal exercise and changes in pVO2 after catheter ablation.
Time frame: Baseline and the follow up testing will be performed 5-6 months (to be more specific: 150-180 days) after catheter ablation.
Correlation between baseline AF burden and LA function, LV Function and pVO2
Correlation between baseline AF burden and LA function (rest and exercise), LV function (rest and exercise), and pVO2
Time frame: Baseline and the follow up testing will be performed 5-6 months (to be more specific: 150-180 days) after catheter ablation.
Correlation between the amount of AF burden reduction and the changes in LA function, LV function (rest and exercise), and pVO2.
Correlation between the amount of AF burden reduction and the changes in LA function (rest and exercise), LV function (rest and exercise), and pVO2.
Time frame: Baseline and the follow up testing will be performed 5-6 months (to be more specific: 150-180 days) after catheter ablation.