The investigators aimed to compare the image quality and diagnostic performance of DECTPA using lower concentration iodine contrast materials and using normal concentration iodine contrast materials in the evaluation of suspected pulmonary embolism.
All patients met the inclusion and exclusion criteria will be given written informed consensus. The enrolled patients will randomly receive one of the three injection protocols: A: 30mL Iomeprol (Iomeron 300, Bracco Imaging, Milano, Italia) injected at a flow rate of 4mL/s; B: 50mL Iomeprol (Iomeron 300, Bracco Imaging, Milano, Italia) injected at a flow rate of 4mL/s; C: 50mL Ioversol (Ioversol 350, Hengrui, Jiansun, China) injected at a flow rate of 4mL/s. A and B groups are both lower concentration iodine contrast material groups, with different total iodine loads.
Study Type
OBSERVATIONAL
Enrollment
2,100
CT images using lower concentration and lower volume contrast material
Wuxi People's Hospital
Wuxi, Jiangsu, China
RECRUITINGimage quality evaluation of the CTPA images of 30% participants
1. the mean CT number (in Hounsfield units) in the main pulmonary artery by using a region of interest of at least 1 square centimeter. 2. the CT number (in Hounsfield units) of peripheral pulmonary arteries close to the beginning and the end of each scan in a egmental or subsegmental artery at an apical and a basal section position. Because the caliber of the peripheral vessels was too small to reliably set an intraluminal region of interest to determine the mean CT number, the maximum CT number as a proxy for vascular attenuation should be chosen. 3. the images quality score for making a diagnosis other than PE ( using a five-point scale ranging from 1 to 5).
Time frame: through the CTPA examinations of 30% participants finished,, an average of six month
overall diagnostic performance for pulmonary embolism
diagnostic accuracy, sensitivity and specificity
Time frame: CTPA examinations all participants are finished, an average of two month
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