Blood Bioavailability of Two Different Doses of a β-alanine Supplement (BIo-β)

Universidad Católica San Antonio de Murcia12 enrolled

Overview

The purpose of this study is to To study the blood bioavailability of a sustained-release β-alanine granulated supplement of two different doses (10 g and 20 g).

Subjects will consume 10 g of β-alanine one day by 4 ingestions of 2.5 g separated by 1 hour and 15 min. While on another day 20 g of β-alanine by 4 ingestions of 5 g separated by 1 hour and 15 minutes, with a washout period of 15 days between the two doses. Subsequently, the amino acid levels in blood will be analyzed after the product intake and during a period of 8 hours. Each day of visit the paresthesias (moment of appearance, intensity and sensations) will be studied at different times.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

TRIPLE

Enrollment

Conditions

Bioavailability

Interventions

Low doseDIETARY_SUPPLEMENT

Consumption of a β-alanine sustained-release supplement, 10 mg by 4 intakes of 2.5, separated by 1 hour and 15 min.

High doseDIETARY_SUPPLEMENT

Consumption of a β-alanine sustained-release supplement, 10 mg by 4 intakes of 5 separated by 1 hour and 15 min.

Eligibility

Sex: MALEMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Men between 18 and 60 years old. * Cyclists with more than two years of cycling experience. * Bicycle training at least twice a week. Exclusion Criteria: * Suffer a lasting injury that prevents you from training in the month prior to surgery. * Subjects with a chronic illness. * Having consumed in the three months prior to the start of the study any β-alanine supplement. * Making changes in diet or exercise during the study. * Inability to understand the informed consent form. * Consumption of other supplements that could alter the results of the study.

Locations (1)

Catholic University of Murcia

Murcia, Spain

Outcomes

Primary Outcomes

Aminoacids in plasma

The complete series of amino acids will be analyzed in plasma, after supplement intake, for 8 hours and at various times after product intakes. A bioavailability curve will be developed for each of these samples.

Time frame: After the first intake of the product, samples will be taken at 15, 30, 45, 60 and 75 minutes. After the fourth and last product intake, samples will be taken at 15, 30, 45, 60, 75, 90, 120, 180 and 240 minutes.

Secondary Outcomes

Paresthesia

It will be recorded by means of a visual analog scale (VAS), drawn with a continuous line of 10 centimeters where the left edge determines "no unusual sensation", translated to 0 in the recording of the data; and on the right edge "more intense sensation", translated to 10.

symptomatology - qualitative question

They should answer if they have felt at any time after the ingestion of β-alanine any symptomatology such as: prickling, itching, tingling, numbness, chills and pain.

Data from ClinicalTrials.gov

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