The goal of this study is to assess the efficacy of intraoperative celiac plexus block (CPB) to reduce opioid consumption following laparoscopic hepato-pancreato-biliary surgery
A bilateral CPB is convenient and safe to perform under the direct laparoscopic vision of the surgeons during surgery; however, perspective data are warranted. The investigators hypothesize that a bilateral CPB using 0.5% ropivacaine will improve the quality of recovery following a laparoscopic hepato-pancreato-biliary surgery. The primary endpoint is the Postoperative opioid use. Secondary endpoints include acute postoperative pain, opioid consumption, the incidence of postoperative nausea or vomiting (PONV), the 15-item quality of recovery questionnaire (QoR-15), length of post-anesthesia care unit (PACU) stay, length of post-operative hospital stay, and chronic post-surgical pain at 90 d after surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
60
Prior to the end of the laparoscopic surgery and any additional procedures, the bilateral celiac plexus block will be performed by the surgeon after identification of the aorta at the superior border of body of pancreas. A 22-gauge spinal needle will be inserted into the retroperitoneal fat on either side of the aorta under direct vision. Needle aspiration will be performed to exclude entry into vessels before administration of the interventional drug. The block will contain 20 mL of 0.5% ropivacaine hydrochloride + 1:400000 adrenaline.
Prior to the end of the laparoscopic surgery and any additional procedures, the bilateral celiac plexus block will be performed by the surgeon after identification of the aorta at the superior border of body of pancreas. A 22-gauge spinal needle will be inserted into the retroperitoneal fat on either side of the aorta under direct vision. Needle aspiration will be performed to exclude entry into vessels before administration of the interventional drug. The block will contain 20 ml of 0.9% normal saline + 1:400000 adrenaline.
Postoperative opioid use
The primary outcome will be morphine equivalent during the first postoperative 24 h
Time frame: Up to 24 h after surgery
Postoperative opioid use
Patients will be recorded for up to 72 h postoperative opioid consumption.
Time frame: Up to 72 h after surgery
Numeric rating scale (NRS) for pain
Patients will be asked to complete a daily diary up to 72 h that records numeric pain rating scale
Time frame: Up to 72 h after surgery
Postoperative vomiting
Incidence of postoeprative vomiting will be recorded for up to 72 h
Time frame: Up to 72 h after surgery
Quality of recovery using the 15-item quality of recovery questionnaire (QoR-15)
Patients will be asked to complete a 15-item quality of recovery questionnaire up to 72 h after surgery
Time frame: Up to 72 h after surgery
Post-anesthesia care unit (PACU) time
Length of PACU stay
Time frame: Through study completion, an average of 1 year
Post-operative hospital time
Length of hospital stay
Time frame: Through study completion, an average of 1 year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.