Exercise and Brain in Coronary Heart Disease

Inclusion Criteria: 1. Men and women aged between 50 and 75 years old, both inclusive (\*Contingency plan: increase the range to 40-75 if we have difficulties to get the study sample) 2. Must have stable coronary heart disease (phase III), proven by invasive coronary angiography or CT with at least one coronary lesion \> 50%. 3. Able to speak and read fluent Spanish. 4. Live in Granada city or surrounding areas (able to come to evaluations and exercise program) 5. Living in community during the study (i.e. independent home, non-assisted living facilities) 6. Ejection fraction ≥ 45%. 7. Functional grade I-II according to the New York Heart Association (NYHA) scale. 8. Sinus rhythm. 9. Stable optimal medical treatment (3 or more drugs at the determined by a cardiologist). 10. Physically inactive, considering: 1) not meeting the WHO recommendations in both the aerobic and strength part, and 2) not to be participating in a planned and structured exercise program at least 3 days per week and for more than 3 months. Both conditions must be met to be included. Note: going for a walk will not be considered an exclusion reason. 11. Classified as cognitively normal according to Stics-m Exclusion Criteria: 1. Used of assisted walking devices. 2. Acute coronary syndrome in the last year, coronary surgery, or percutaneous intervention in the last 6 months. 3. Treatment for any type of cancer in the last 2 years. 4. Severe hospitalization in the intensive care unit in the last 6 months. 5. Current psychiatric diagnosis (visit to psychiatrist and drug treatment prescription in the last year), including major depression and history of psychiatric illness (schizophrenia, bipolar disorder, hallucinations). 6. Grade III obesity. 7. Diagnosis of neurological or cerebrovascular disorder (e.g. stroke). 8. Medical contraindication for inclusion in an exercise program. 9. Diabetes with uncontrolled glycemia. 10. Resting blood pressure \> 180/110. 11. Chest pain with exertion or changes in the ST segment suggestive of severe ischemia during ergometry. 12. Severe inducible ischemia 13. Functional capacity in ergometry (\<5 METS). 14. Obstructive left main artery disease (significant disease \> 50%) 15. Unstable angina 16. Uncontrolled cardiac arrhythmia 17. Presence of metal implants (e.g., pacemaker or implantable cardioverter-defibrillator-ICD) not compatible with MRI (reported during the phone screening) 18. Paroxysmal or persistent atrial fibrillation with episodes in the last 6 months. 19. Moderate to severe pulmonary hypertension. 20. Acute endocarditis, myocarditis, or pericarditis. 21. Moderate to severe valve disease (grade 3-4) 22. Acute pulmonary embolism, or deep vein thrombosis. 23. Aortic dissection 24. High-grade heart block or complete left bundle branch block or altered basal electrocardiogram with difficulties to interpret in exercise testing. 25. Hypertrophic obstructive cardiomyopathy. 26. Retinopathy. 27. Severe autonomic or peripheral neuropathy. 28. Acute systemic illness or fever. 29. Acute or chronic renal failure (estimated glomerular filtration rate \< 30 mL/min) 30. Pulmonary fibrosis or interstitial disease (respiratory failure or severe COPD confirmed by pneumological study). 31. Recent treatment for alcohol or substance abuse. 32. Claustrophobia. 33. Any surgery or medical intervention planned during the study period. 34. Plans to participate or current participation in other studies that might interferes with this study. 35. Current pregnancy or intention to get pregnant during the study period