Frailty among patients undergoing surgery is strongly associated with an elevated risk of adverse perioperative outcomes, heightened incidence of postoperative complications, increased mortality rates, and prolonged hospital length of stay. Our focus centers on investigating the frailty index in the context of complications experienced by patients undergoing oncologic gynecology surgery. The principal objective of this research is to elucidate the extent to which residual neuromuscular blocking agents are linked to frailty.
Among patients undergoing oncologic gynecological procedures, such as those for vulvar cancer, endometrial cancer, and ovarian cancer, the incidence of frailty has been observed to range from 14% to 45%. Frailty directly influences the metabolism of anesthetic agents and intraoperative management. Furthermore, the prevalence of residual neuromuscular blocking agents following surgery can be as high as 26% to 53%. No prior research has investigated the correlation between residual muscle relaxants and frailty in gynecologic oncology patients. This study is designed to assess the prevalence of residual muscle relaxants in these patients with frailty. Additionally, data on the incidence of frailty and its impact on postoperative outcomes and prognosis in patients undergoing gynecologic oncology surgery will be collected and reported.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
622
Patient receive nerve stimulation by TOF-scan equipment at recovery room after surgery.
Anesthesiology department, Siriraj hospital, Mahidol University
Bangkok, Bangkok, Thailand
RECRUITINGIncidence of residual neuromuscular blockade
Incidence of residual neuromuscular blockade with the relation of frailty after gynecologic oncology surgery
Time frame: 0-30 minute after surgery
Incidence of frailty
Incidence of frailty in patients undergoing gynecologic oncology surgery
Time frame: 0 - 24 hours preoperative
Anesthetic technique used
Anesthetic technique used in patients undergoing gynecologic oncology surgery
Time frame: Throughout Intraoperative period, an average 3-5 hours
Rate of blood transfusion
Quantity of units blood transfusion
Time frame: Throughout Intraoperative period, an average 3-5 hours to 24 hours postoperative
Rate of vasopressor usage
Rate of vasopressor usage eg. ephedrine, norepinephrine
Time frame: Throughout Intraoperative period, an average 3-5 hours to 24 hours postoperative
Length of hospital stay
Total number of days of hospital stay
Time frame: Through study completion, an average of 1 year, an average 3 - 5 days
Rate of intensive care unit admission
Number of patients who require intensive care unit admission after surgery
Time frame: 0 - 24 hours postoperative
Rate of re-intubation
Number of patients who require re-intubation
Time frame: 0 - 24 hours postoperative
Rate of postoperative mechanical ventilation
Number of patients who require mechanical ventilation postoperative
Time frame: 0 - 24 hours postoperative
Rate of postoperative pulmonary complications
Number of patients who have postoperative pulmonary complications eg. prolonged intubation, atelectasis, pneumonia etc.
Time frame: 3 days after operation
Mortality rate
Number of patients who died after surgery
Time frame: 30 days after operation
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