Current Chinese dietary iodine reference intake (DRIs) standards lack direct data on recommended iodine intake (RNI) in the elderly. The elderly have a high prevalence of thyroid diseases. The risk threshold of iodine intake in the elderly is unknown. Identifying the appropriate iodine intake for the elderly to maintain optimal thyroid function to reduce the burden on medical resources is a public health issue requiring high attention. The iodine balance study is an important method for exploring physiological iodine requirements. Few iodine balance studies have been conducted in the elderly. This study aimed to conduct an iodine balance study and provide information on the appropriate iodine intake level for elderly people.
The investigators measured subjects' food and water intake throughout the day using weighing methods, and collected all urine and fecal samples. Food, drinking water, fecal and urine samples were taken to determine iodine concentrations. Each subject was required to participate in two phases of iodine balance studies. Each stage lasts 4 to 10 days. There was no intervention in the first half of the experiment, and there was an intervention of iodized salt/non-iodized salt consumption in the second half of the experiment. The appropriate level of iodine intake for the elderly was explored by fitting and analyzing the dose change relationship between iodine intake and iodine excretion.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Enrollment
30
Replace subjects' iodized salt with non-iodized salt.
Gansu provincial center for disease control and prevention
Lanzhou, Gansu, China
RECRUITINGShandong provincial institute for endemic disease control
Jinan, Shandong, China
RECRUITINGTianjin Medical University
Tianjin, Tianjin Municipality, China
RECRUITINGIodine intake
Daily iodine intake includes dietary iodine intake and drinking water iodine intake.
Time frame: Each phase of the iodine balance study lasts 4 to 10 days.
Iodine excretion
Daily iodine excretion includes urinary iodine excretion and fecal iodine excretion.
Time frame: Each phase of the iodine balance study lasts 4 to 10 days.
thyroid function indexes
FT3、FT4、TSH、TPOAb、TGAb. Each subject was asked to collect venous blood twice (before the experiment and within one week after the intervention) to measure indicators of thyroid work.
Time frame: Within one week before the start of the experiment.
thyroid volumn
Thyroid volume was measured using thyroid B-ultrasound.
Time frame: Within one week before the start of the experiment.
salivary iodine
Every time the subject urinates, 2ml of saliva is collected.
Time frame: 4 to 10 days
blood pressure
Subjects had their blood pressure measured before and after the study.
Time frame: Within one week before the start of the experiment.
fasting blood glucose
Subjects had their fasting blood glucose measured before and after the study.
Time frame: Within one week before the start of the experiment.
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