Laser sources have established their potential effect in inducing hair regrowth. No study has compared the effect of ablative fractional 2940-nm erbium yttrium aluminum garnet (Er: YAG) laser and non-fractional 15650nm fractional laser in the treatment of androgenetic alopecia (AGA).
The investigators performed a prospective study between to compare the efficacy and safety of ablative fractional 2940-nm erbium yttrium aluminum garnet (Er: YAG) laser and non-fractional 15650nm fractional laser in the treatment of androgenetic alopecia (AGA). The efficacy of the two therapies was evaluated by the investigator's Global Assessment (IGA) scores and the patient's Likert satisfaction scale at week 12 and week 24. Changes in total, terminal and villous hair count, total and terminal hair diameter, and AGA grade were also recorded. Adverse events were evaluated at each follow-up.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
135
Ablative fractional 2940-nm Er: YAG laser (Dermablate MCL31, Asclepion Laser Technologies, Germany), the following parameters were used: model of N25%, energy density of 20-30J/cm2, pulse time of 300μs and one to two passes.
Non-ablative fractional 1565nm (Lumenis, M22): Resur Fx len, energy of 30-35J/cm2, density of 200spot/cm2, overlap ≤10%.
topical 5% minoxidil, 1 ml, twice daily
Second Affiliated Hospital, School of Medicine, Zhejiang University, China
Hangzhou, Zhejiang, China
RECRUITINGTAHC
Use the trichoscopy to assess the changing number of non-vellus hairs in the target area .
Time frame: week 24
HGQA
Hair growth questionnaire assessment
Time frame: week 8, week 12, week 16, week 24, week 36
TAHC
Use the trichoscopy to assess the changing number of non-vellus hairs in the target area
Time frame: week 8, week 12, week 20, week 36
TAHW
Use the trichoscopy to assess the changing diameter of non-vellus hairs in the target area
Time frame: week 8, week 12, week 16, week 24, week 36
IGA
Investigator's Global Assessment. IGA was evaluated using a 7-point scale as follows: -3= obvious reduction of hair; -2= moderate reduction of hair; -1= mild reduction of hair; 0= change; 1= mild growth of hair; 2= moderate growth of hair; 3= obvious growth of hair.
Time frame: week 8, week 12, week 16, week 24, week 36
Grade of Norwood-Hamilton
The Grade of Norwood-Hamilton Classification
Time frame: week 12, week 24, week 36
SSA
Subject self-assessment. SSA was evaluated using a 7-point scale as follows: -3= obvious reduction of hair; -2= moderate reduction of hair; -1= mild reduction of hair; 0= change; 1= mild growth of hair; 2= moderate growth of hair; 3= obvious growth of hair.
Time frame: week 8, week 12, week 16, week 24, week 36
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