The purpose of this study is to investigate new quantitative MRI-sequences for assessment of age-specific data for the prediction of brain aging.
After being informed about the study, healthy controls and patients with multiple sclerosis giving written informed consent will undergo blood examination (for determination of the biological age using the publicly available R-package algorithm BioAge), clinical examination (for motor, cognitive and psychological parameters) as well as an MRI-investigation with chemical exchange saturation transfer (CEST) and T1-relaxometry on a 7 Tesla MRI. Data from the healthy controls will be used to set up a normative brain age data set, that could be used for example to train a model for brain age prediction.
Study Type
OBSERVATIONAL
Enrollment
200
Inselspital Bern
Bern, Canton of Bern, Switzerland
RECRUITINGBrain Age Gap in patients with MS
Difference between estimated brain age and (A) biological as well as (B) chronological age.
Time frame: Up to 2 months after recruitment or finalization of MRI-visit, whichever came first.
Relationship of brain age gaps with disease severity
Relationship of brain age gaps with disease severity as measured by the expanded disability and severity scale (EDSS; min.-max. according to eligibility criteria: 0-6 points, with a higher score meaning a higher degree of disease severity)
Time frame: Up to 2 months after recruitment or finalization of MRI-visit, whichever came first.
Relationship of brain age gaps with gait speed
Relationship of brain age gaps with gait speed as measured by the 25-foot walking test
Time frame: Up to 2 months after recruitment or finalization of MRI-visit, whichever came first.
Relationship of brain age gaps with upper extremity function
Relationship of brain age gaps with upper extremity function as measured by the 9-hole Peg Test
Time frame: Up to 2 months after recruitment or finalization of MRI-visit, whichever came first.
Relationship of brain age gaps with sitting-to-raise time
Relationship of brain age gaps with a raising test using the sitting-to-raise time
Time frame: Up to 2 months after recruitment or finalization of MRI-visit, whichever came first.
Relationship of brain age gaps with cognitive symptoms
Relationship of brain age gaps with cognitive (brief international cognitive assessment in multiple sclerosis (BICAMS))
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Time frame: Up to 2 months after recruitment or finalization of MRI-visit, whichever came first.
Relationship of brain age gaps with depression symptoms
Relationship of brain age gaps with depression symptoms as assessed with the brief depression inventory (BDI)
Time frame: Up to 2 months after recruitment or finalization of MRI-visit, whichever came first.
Relationship of brain age gaps with fatigue
Relationship of brain age gaps with fatigue as assessed with the fatigue severity score (FSS)
Time frame: Up to 2 months after recruitment or finalization of MRI-visit, whichever came first.
Relationship of brain age gaps with quality of life
Relationship of brain age gaps with experienced quality of life as assessed with the Multiple Sclerosis Impact Scale (MSIS)-29
Time frame: Up to 2 months after recruitment or finalization of MRI-visit, whichever came first.