Synaptic loss has been implicated in various neurodegenerative conditions, yet its understanding in multiple system atrophy (MSA) remains limited. The aim of this study was to examine spatial synaptic density alterations in MSA patients and evaluate the potential of \[18F\]SynVesT-1 PET as an imaging biomarker for MSA in both diagnosis and monitoring disease severity.
60 MSA patients (30 MSA-P subtype and 30 MSA-C subtype) and 30 age-matched healthy controls (HCs) underwent \[18F\]SynVesT-1 PET/CT for synaptic density assessment. Visual, voxel, and volumetric region-of-interest (VOI) analyses were employed to elucidate synaptic density patterns in the MSA brain and establish visual diagnostic criteria. VOI-based computer-assisted analyses were utilized to develop diagnostic models for MSA.
Study Type
OBSERVATIONAL
Enrollment
90
60 MSA patients (30 MSA-P subtype and 30 MSA-C subtype) and 30 age-matched healthy controls (HCs) underwent \[18F\]SynVesT-1 PET/CT for synaptic density assessment
Jian Li
Changsha, Hunan, China
Spatial synaptic density alterations in MSA patients
To examine spatial synaptic density alterations in MSA patients
Time frame: 10 months
[18F]SynVesT-1 PET as an imaging biomarker for MSA
evaluate the potential of \[18F\]SynVesT-1 PET as an imaging biomarker for MSA
Time frame: 10 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.