Effect of PVE on Surgical Outcomes and Long-term Survival in Perihilar Cholangiocarcinoma

Seoul National University Hospital136 enrolled

Overview

Portal vein embolization is often recommended to reduce the risk of postoperative liver failure and mortality. In this retrospective cohort study, researchers investigated the effect of portal vein embolization in patients with resectable perihilar cholangiocarcinoma bismuth type III and IV.

Study Type

OBSERVATIONAL

Enrollment

136

Conditions

Biliary Tract Cancer Portal Vein Embolization

Interventions

Potal vein embilizationPROCEDURE

Portal vein of involved bile duct is embolized to increase the volume of remnant liver.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: 1. patients with Bismuth type III or IV stricture on radiological examination, including computed tomography (CT) or magnetic resonance cholangiography 2. patients with perihilar cholangiocarcinoma histologically confirmed by surgical resection or forceps biopsy/brush cytology under endoscopic retrograde cholangiopancreatography or through the percutaneous transhepatic biliary drainage tract. Exclusion Criteria: 1. patients with unresectable perihilar cholangiocarcinoma 2. patients who refused treatment 3. patients with other concomitant malignancies.

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Overall survival

Overall survival of each group (A-C).

Time frame: The time from diagnosis until the date of death or last date of follow-up or end of study up to 24 months

Secondary Outcomes

Recurrence free survival

Recurrence free survival of patients who underwent surgical resection

Time frame: The time from surgical resection until the date of recurrence or death or last date of follow-up or end of study up to 24 months

Data from ClinicalTrials.gov

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