MR Image Synthesis With Low Gadobutrol Dose and AI

Inclusion Criteria: 1. At the time of signing the informed consent at least 18 years of age and less than or equal to 89 years of age. 2. Have known or highly suspected brain lesions referred for contrast-enhanced MRI of the CNS. 3. Have an estimated glomerular filtration rate (eGFR) value ≥ 60 mL/min/1.73m\^2. 4. Be fully informed about the study, including provisions of the Health Insurance Portability and Accountability Act (HIPAA) as applicable, and being capable and willing to consent to participate. Exclusion Criteria: 1. Considered clinically unstable or has a concomitant/intercurrent condition that would not allow participation in the study. 2. Diagnoses of multiple sclerosis or other disease process that is expected to change its enhancement pattern in the time period of the follow-up. 3. Brain pathology or abnormalities that are not considered lesions. 4. Any contraindication for MRI procedure or gadobutrol administration. 5. Has severe cardiovascular disease. 6. Is expected or is scheduled to have a change in any treatment or procedure between the two study periods that may alter image comparability. 7. Is scheduled or is likely to require a biopsy or any interventional therapeutic procedure from the first study MRI up to 24 hours after the second study MRI. 8. Women currently lactating, pregnant, or planning on becoming pregnant during the study. 9. Women of childbearing potential with a positive urine pregnancy test within 24 hours before either gadobutrol administration. 10. Receipt of any gadolinium-based contrast agent \<72 hours prior to the study MRIs. 11. Participants with acute kidney injury.