Effect of Periodontal Treatment on Adipokine Levels

Marmara University80 enrolled

Overview

The present study aimed to determine the effect of non-surgical periodontal treatment (NSPT) on serum and salivary adipokine and interleukin-1β levels in periodontitis patients with or without type 2 Diabetes Mellitus (T2DM).

The present study aimed to determine the effect of non-surgical periodontal treatment (NSPT) on serum and salivary adipokine and interleukin (IL)-1β levels in periodontitis patients with or without type 2 Diabetes Mellitus (T2DM). A total of 80 patients; 20 healthy, 20 T2DM with periodontitis (P), 20 T2DM periodontally healthy, 20 systemically healthy with P were included in this study. At baseline, serum and saliva samples were collected and the whole mouth clinical periodontal parameters were recorded. Periodontitis patients received NSPT in 4 sessions. Clinical parameters were re-measured and samples were re-collected at 1 and 3 months after treatment. Serum and salivary levels of adipokines and IL-1β were analyzed using a flow cytometry-based technique of Lumina® map™. Data were analyzed using appropriate statistical tests.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Periodontitis Diabetes Mellitus, Type 2

Interventions

Non-surgical periodontal treatmentPROCEDURE

Non-surgical periodontal treatment was performed in a quadrant-wise manner at 1-week intervals.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Diabetes mellitus should be diagnosed for ≥1 year and HbA1c level should be at least %6,5 * Periodontitis should be diagnosed for at least 4 teeth with probing depth ≥5 mm with bleeding on probing (BOP) and also radiographic alveolar bone loss should be presence * Presence of at least 15 teeth Exclusion Criteria: * Received antibiotic treatment in the previous 3 months * Smokers * Pregnancy and lactation * Received periodontal treatment in the previous 6 months * Presence of less than 15 teeth * Having major diabetic complications

Locations (2)

Department of Periodontology, Institute of Dentistry, Turku University

Turku, Lemminkäisenkatu 2, Finland

Marmara University, Faculty of Dentistry, Department of Periodontology

Istanbul, Maltepe, Turkey (Türkiye)

Outcomes

Primary Outcomes

Serum and Salivary Resistin Levels (pg/ml)

Serum and salivary resistin levels

Time frame: Change between baseline, 1 and 3 months after non-surgical periodontal treatment

Serum and Salivary Leptin Levels (pg/ml)

Serum and salivary leptin levels

Time frame: Change baseline, 1 and 3 months after non-surgical periodontal treatment

Serum and Salivary Visfatin Levels (pg/ml)

Serum and salivary visfatin levels

Time frame: Change baseline, 1 and 3 months after non-surgical periodontal treatment

Serum and saliva IL-1β levels (pg/ml)

Serum and salivary IL-1β levels

Time frame: Change baseline, 1 and 3 months after non-surgical periodontal treatment

Secondary Outcomes

HbA1c ( %)

Glycated Hemoglobin Level %

Time frame: Change baseline, 1 and 3 months after non-surgical periodontal treatment

Data from ClinicalTrials.gov

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