Determine the levels of Donor-derived (dd)cell-free DNA(cfDNA )in liver transplant recipients with normal liver function tests (LFTs) indicating stable immunosuppression status (IS). Based on this range use the dd-cfDNA levels to determine over or under IS in liver transplant patients to make changes to their IS medication regimen.
dd-cfDNA is a non-invasive method to measure graft function stability in liver transplant patients. Liver biopsy is the standard to determine liver rejection and graft function, but no tests exist currently to be able to help guide the IS regimen in these patients. LFTs are not as specific to determine graft function hence testing dd-cfDNA levels can help guide the Immunosuppression (IS )medications dosing and help identify rejection early.
Study Type
OBSERVATIONAL
Enrollment
300
Determine the difference in age, gender, LFTs, IS regimen (tacrolimus/sirolimus/cyclosporin with mycophenolate mofetil (MMF) and /or prednisone) between patients who underwent liver transplant \<1 year PTX and \>1 year PTX
Methodist Dallas Medical Center
Dallas, Texas, United States
RECRUITINGdd-cfDNA range in liver transplant patients
Determine the dd-cfDNA in liver transplant patients with stable IS collected from July 2021 to July 2024 and compare the range between patients with \<1-year post-transplant (PTX) and \>1-year PTX by chart review using Methodist hospital data system.
Time frame: 1 year
Demographics: age (years), gender (male/female), race (Caucasian, Black, Hispanic, Asian, Other)
Demographics differences in patients who underwent liver transplant less than 1 year of PTX and more than 1 year PTX
Time frame: 1 year
Days post-transplant at first dd-cfDNA
Number of days post transplant at first dd-cfDNA
Time frame: 1 year
LFTs: Alanine transaminase(ALT), Aspartate transaminase(AST),Alkaline phosphatase( ALP), total bilirubin (Tbili)
looking at the liver function tests in patients who underwent liver transplant less than 1 year of PTX and more than 1 year PTX
Time frame: 1 year
Serum Creatinine
Measuring the serum creatinine levels
Time frame: 1 year
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