Mechanism of IL-10 Pathway-mediated Regulatory B Cell Dysfunction in Osteoarthritis

Shufeng Li40 enrolled

Overview

Our previous work has shown that Treg function is impaired in OA patients, but the cause of Treg deficiency has not been investigated. Since Breg has been shown to promote Treg differentiation and tissue repair, it is highly likely that the absence of the immunomodulatory effect of Breg in OA patients leads to impaired Treg differentiation. Based on the above data, we hypothesized that Breg plays a protective role in the course of OA by regulating T cell composition and promoting Treg differentiation through the secretion of anti-inflammatory factor IL-10

Study Type

OBSERVATIONAL

Enrollment

Conditions

Osteoarthritis Knee Arthritis

Eligibility

Sex: ALLMin age: 40 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria:Patients who met the American College of Rheumatology diagnostic criteria for OA \- Exclusion Criteria: * Patients with trauma, other forms of arthritis such as rheumatoid arthritis, psoriatic arthritis or spondyloarthritis, and other active inflammatory diseases

Locations (1)

The First Affiliated Hospital of Shandong First Medical University

Jinan, Shandong, China

Outcomes

Primary Outcomes

Number of Breg

Regulatory B cells

Time frame: 4 and 8 weeks after DMM

Secondary Outcomes

Cytokine secretion by T cells

Regulatory T cells

Time frame: 4 and 8 weeks after DMM

Data from ClinicalTrials.gov

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