Acute calculous cholecystitis (ACC) is the second most frequent surgical condition in emergency departments. The recommended treatment is surgical treatment (ST) and the accepted mortality is \<1%, but in severe and/or fragile patients is higher. Despite the Tokyo Guidelines, there no consensus on who is the unfit patient for ST. A recent study has identified 4 risk factors that predicts the mortality in a 92% of patients (ACME) and could help to develop new guidelines in ACC. The aim of this study is to perfom an external validation of the new simplified scoring system for mortality in ACC.
This is a prospective multicenter observational study of 10.000 adults with ACC during 2 consecutive years (2025/2026), including baseline demographic characteristics, comorbidity severity defined as Charlson Comorbidity Index (CCI), ASA Score, Tokyo Guidelines severity classification and the new ACME Scoring system. The primary outcome is to study the prediction of mortality of ACME score. Secondary outcomes include complications following Clavien-Dindo's classification, C-statistic, and ROC Curves.
Study Type
OBSERVATIONAL
Enrollment
10,000
Mortality
Describe the mortality in the cohort and its causes
Time frame: Jan 2025- Dec 2026
Complications
Describe the mortality in the cohort by Clavien-Dindo's classification
Time frame: Jan 2025- Dec 2026
ACME's prediction of mortality
To describe the prediction in a ROC Curve of ACME Scoring System with C-Statistic
Time frame: Jan 2025- Dec 2026
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.