Association Between EEG Changes and Hormonal Response to Tracheal Intubation and Surgical Stimulation

Seoul National University Hospital52 enrolled

Overview

This study aims to prospectively evaluate the relationship between changes in EEG and hormonal responses induced by endotracheal intubation and surgical incision following general anesthesia.

This study aims to investigate the relationship between changes in EEG patterns and stress hormone levels in patients undergoing open abdominal surgery under general anesthesia when subjected to endotracheal intubation and surgical incision stimuli. Hormone measurements (cortisol, ACTH) are taken at four time points: before endotracheal intubation (T1), one minute after intubation (T2), and one minute after surgical incision (T3). The investigators evaluate the correlation between hormone levels (cortisol, ACTH) and EEG band power changes (alpha, beta, delta) before and after endotracheal intubation and surgical incision.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Abdominal Surgery Endotracheal Intubation Surgical Incision Electroencephalogram

Interventions

Endotracheal intubationPROCEDURE

Inserting endotracheal tube into the trachea

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 1\) Patients scheduled to undergo open abdominal surgery under general anesthesia with endotracheal intubation. * 2\) Patients requiring invasive blood pressure monitoring during surgery Exclusion Criteria: * 1\) Patients transferred to the intensive care unit after surgery * 2\) Surgery duration of less than one hour * 3\) Patients with neurological underlying conditions * 4\) Patients on chronic use of psychotropic medications and opioid drugs * 5\) Emergency surgery

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Association between band power changes in EEG and hormone respones caused by endotracheal intubation

Time frame: from the start of anesthesia induction to one minute after endotracheal intubation

Secondary Outcomes

Association between band power changes in EEG and hormone respones caused by surgical incision

Time frame: from the start of anesthesia induction to one minute after surgical incision

Data from ClinicalTrials.gov

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