Gut Microbiota in Patients With Limb Lymphedema and Recurrent Lymphangitis

Inclusion Criteria (Group A): * 18-85 years * primary or secondary, upper or lower limb lymphedema, I-II-III stage ISL * at least 3 episodes of soft tissue infection in an year, in the last 2 years * consent to participate in the study Inclusion Criteria (Group B): * 18-85 years * primary or secondary, upper or lower limb lymphedema, stage I-II-III (ISL) * no episodes of soft tissue infection in the last 2 years * consent to participate in the study Exclusion Criteria: * No compliance to perform limb compression and skin hygiene * Antibiotic therapy in the last 15 days * Diabetes mellitus * Immunodeficiency * Ongoing neoplastic pathology * Taking immunosuppressive drugs * Unavailability to follow-up for at least 24 months post-enrollment.