Safety and Efficacy of Intrapulmonary Percussive Ventilation in Preterm Infants

Augusta University10 enrolled

Overview

The purpose of this study is to evaluate the benefits and safety of Intrapulmonary Percussive Ventilation in preterm infants. IPV has been demonstrated to be safe, and improve airway secretions clearance and decreased atelectasis in pediatric patients. We aim to evaluate the effects of IPV in preterm infants.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Respiratory Distress Syndrome in Premature Infant

Interventions

Intrapulmonary Percussive VentilationDEVICE

IPV applied at increasing intervals, starting every 6 hours, and ending at every 24 hours, for a total of 7 days.

Eligibility

Sex: ALLMin age: 14 Days

Medical Language ↔ Plain English

INCLUSION CRITERIA * Premature infants born before 32 weeks of gestation with birth weight less than 1500 grams. * Infants requiring positive pressure ventilation by 14 days of life. EXCLUSION CRITERIA * Infants with known or suspected chromosomal anomalies (Trisomy 13, 18, 21) * Infants with Congenital Diaphragmatic Hernia * Presence of air leak syndrome (pneumothorax, pneumomediastinum) * Previous diagnosis of air leak syndrome.

Outcomes

Primary Outcomes

Mechanical ventilation and supplemental oxygen

Need for mechanical ventilation and supplemental oxygen administration

Time frame: From the date of starting treatment protocol to 2 weeks after.

Secondary Outcomes

Diagnosis of Bronchopulmonary Dysplasia

Need for mechanical ventilation and supplemental oxygen administration

Time frame: At 36 weeks gestational age

Data from ClinicalTrials.gov

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