Hydrolyzed Collagen and Undenatured Collagen Type II in OA Knee

Prince of Songkla University68 enrolled

Overview

Randomized controlled trial Targeted patients who come to receive treatment for osteoarthritis that meets the research indications will be assigned to a random group by the box of 4 randomization method, with a sequence that is randomly generated by a computer. The groups are divided into two groups: Group 1: Patients who have taken 480 mg of hydrolyzed collagen and 20 mg of undenatured type II collagen Group 2: Control patients will take placebo Primary outcome : Pain level

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Osteo Arthritis Knee

Interventions

CollagenDIETARY_SUPPLEMENT

Patients who have taken 480 mg of hydrolyzed collagen and 20 mg of undenatured type II collagen (in one tablet) 2 tabs a day

PlaceboOTHER

Control patients will take placebo 2 tabs a day.

Eligibility

Sex: ALLMin age: 50 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age: 50-80 years old * Medial compartment knee osteoarthritis * Kellgren and Lawrence classification stage 2 -3 * Able to walk without walking aid Exclusion Criteria: * History of knee surgery on the study side * History of intra-articular steroid injection within 6 months prior to study entry * Systemic arthritis conditions * Degenerative neurological and muscular conditions in the lower extremities * Chronic kidney disease with CrCl \< 30 ml/min (glomerular filtration rate \<60 mL/min/1.73 m2)

Locations (1)

Prince of Songkla University

Hat Yai, Changwat Songkhla, Thailand

Outcomes

Primary Outcomes

Pain (VNRS)

Pain level (verbal numerical rating scale :VNRS) - 0 is no pain and 10 is the worst pain

Time frame: 12 weeks

Secondary Outcomes

Knee and Osteoarthritis Outcome Score (KOOS)

Knee and Osteoarthritis Outcome Score (KOOS) - 100 indicates the best possible results and 0 the worst outcome

Time frame: 12 weeks

Rescue medication

Amount of pain medication intake

Time frame: 12 weeks

Patient satisfaction

Patient satisfaction (verbal numerical rating scale :VNRS) - (0-10; 0=worst and 10=best)

Time frame: 12 weeks

Data from ClinicalTrials.gov

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