Currently, continuous renal replacement therapy (CRRT) is the main modality for renal support in critically ill patients with hemodynamic instability. Most studies have investigated the timing of RRT initiation. However, prolonged CRRT demonstrated the association of many unexpected events, such as catheter-related complications, catheter-related blood stream infection, hypotension, hypothermia, tachycardia, and atrial fibrillation. Up to now, there is a lack of evidence regarding the timing of withholding CRRT. The furosemide stress test (FST) is a tool that is easy to use and has more availability. The investigators aimed to apply FST to evaluate renal recovery compared with standard treatment in critically ill patients undergoing CRRT.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
80
After taking furosemide at 1.5 mg/kg intravenously, if the urine output exceeds 200 mL within 2 hours, the patients are going to withhold CRRT. But if there is no response, the titration of furosemide to 2.5 mg/kg and 3.5 mg/kg every 6 hours is scheduled according to the urine output \>200 mL in 2 hours (not exceeding 250 mg).
Chiang Mai University
Chiang Mai, Thailand
RECRUITING% of patients with Renal recovery
Free of RRT for at least 5 days
Time frame: 5 days
% of patients with Mortality
28 days all cause mortality and in-hospital mortality
Time frame: 28 days
RRT free days
No need to restart RRT
Time frame: 28 days
Day of Hospitalization
Length of hospital stay and ICU stay
Time frame: 28 days
Ventilator-free day
Number of mechanical ventilator-free day
Time frame: 28 days
% of complication
CRBSI, electrolyte imbalance, urine output
Time frame: 28 days
Cost of RRT during hospitalization
The cost of RRT since the initiation until the end of RRT during hospitalization in US dollar and Thai Baht unit
Time frame: 28 days
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