Clinical Study of Individualized Treatment of Relapsed or Drug-resistant Advanced Gynecological Tumors Guided by PTC Model

Inclusion Criteria: 1. Age ≥18 years, ≤80 years 2. Recurrent/drug-resistant gynecological tumors include: ① patients with advanced high-grade ovarian serous cancer whose tumor is uncontrolled or recurrent within 6 months after receiving platinum-based chemotherapy; ② Advanced ovarian high-grade serous cancer patients with platinum resistance at first treatment; ③ Patients with advanced or recurrent endometrial adenocarcinoma. 3. Life expectancy \> 6 months; 4. Malignant tumors that are not being treated by other systems or are in an active phase; 5. Have at least one measurable target lesion according to RECIST1.1 criteria; 6. Specimen requirements: fresh specimens with sufficient cell culture, including tissue samples and abdominal effusion; 7. Physical strength score: ECOG 0-2; 8. Major organ functions must meet clinical treatment requirements: * Blood routine: neutrophil (ANC) ≥1.5x109/L; Platelet count (PLT) ≥90x109/L; Hemoglobin (Hb) ≥90g/L; ② Blood biochemistry: total bilirubin (TBIL) ≤1.5x upper limit of normal value (ULN); Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤1.5xULN; Urea nitrogen (BUN) and creatinine (Cr) ≤1.5 x ULN (3) Heart color ultrasound: left ventricular ejection fraction (LVEF) ≥55%; ④ 12-lead ECG: Fridericia method corrected QT period (QTcF) \< 470 msec. (9) Consent to abstinence from sex or use of an effective contraceptive method during treatment and for at least 7 months after the last dose in the study treatment for female patients who are not menopausal or have not been surgically sterilized; (10) Patients participating in the study (or their legal representatives) understand and voluntarily sign informed consent, have good compliance, and are willing to cooperate with follow-up. Exclusion Criteria: 1. Patients who are unable to provide sufficient fresh samples; 2. pregnant and lactating women, female patients with fertility and positive pregnancy tests, or patients of childbearing age who are unwilling to take effective contraceptive measures during the whole test period; 3. The patient has uncontrollable co-morbidity, including but not limited to: symptomatic congestive heart failure, unstable angina pectoris and myocardial infarction, uncontrolled grade III hypertension, liver insufficiency, renal insufficiency, diabetes uncontrolled blood sugar, arrhythmia and mental illness; 4. Other circumstances in which the investigator determines that participation in the study is not appropriate.