Attention Deficit Hyperactivity Disorder

Nantes University Hospital60 enrolled

Overview

The ADA cohort aims for the systematic and standardized collection of sociodemographic, clinical and neuropsychological data, during 2 visits (inclusion and 12 months), from patients suffering from the co-occurrence of ADHD (Attention Deficit Hyperactivity Disorder) and addiction(s), in addition to the treatment as usual adapted to each situation.

Information on the study and diagnosis of ADHD will be carried out during a medical evaluation consultation, as part of routine care. The two research visits (inclusion and at 12 months) will be added by the research and will each include: * A structured clinical interview with a research professional (traceability of oral consent, administration of structured interviews, collection of self-questionnaires, collection of care from the medical record) * A neuropsychological assessment with a neuropsychologist

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Attention Deficit Hyperactivity Disorder Behavior Hyperactive Behavior Disorders

Interventions

Patients suffering from the co-occurrence of ADHD and addiction(s)OTHER

All eligible patients over 15 years and 3 months (age limit between child psychiatry and adult psychiatry), presenting both a diagnosis of ADHD and a diagnosis of at least one addictive disorder (SUD, AUD (Alcohol Use Disorder) and/ or behavioral addiction), starting care in one of the three participating centers, and meeting the indication for treatment with MPH according to European recommendations (J. J. S. Kooij et al., 2019)

Eligibility

Sex: ALLMin age: 15 YearsMax age: 99 Years

Medical Language ↔ Plain English

Inclusion Criteria : * Patients aged over 15 years and 3 months * For whom a diagnosis of ADHD has been confirmed less than 6 weeks ago * For whom the diagnosis of one or more addictive disorder(s) (substance use disorder or behavioral addiction) has been confirmed * Meeting the indication for treatment with MPH according to European recommendations (Kooij et al., 2019) * For patients who can actually benefit from MPH: who have not yet started taking MPH * Social security affiliates Exclusion Criteria : * Presenting disorders of higher cognitive functions (at the discretion of the referring clinician or the investigator making the inclusion), making data collection impossible * Presenting difficulties in reading or writing the French language making data collection impossible * Unable to commit to being available for the 2 visits planned as part of the cohort * Under guardianship or legal protection

Locations (3)

Nantes University Hospital

Nantes, Loire-Atlantique, France

RECRUITING

CHRU de Brest

Brest, France

RECRUITING

CHRU de Tours

Tours, France

RECRUITING

Outcomes

Primary Outcomes

Functional impairment

Weiss Functional Impairment Rating Scale (WFIRS-S) (scores of the 7 domains and total score)

Time frame: Inclusion and 12-month follow-up

Secondary Outcomes

Type and severity of ADHD

Diagnostiscal Interview Voor Attention deficit hyperactivity disorder (DIVA-5)

Time frame: Inclusion

Symptoms of ADHD

Adult ADHD Self-Report Scale Symptom Checklist (ASRS-1.1) (inattention and hyperactivity/impulsivity scores)

Time frame: Inclusion and 12-month follow-up

Addictive disorders - substance use disorders (including tobacco, alcohol and other substances)

Mini International Neuropsychiatric Interview- Simplified for Diagnostic and Statistical Manual (DSM)-5 (MINI-S)

Time frame: Inclusion and 12-month follow-up

Addictive disorders - gambling disorder

National Opinion research center DSM Screen for gambling problems (NODS)

Time frame: Inclusion and 12-month follow-up

Addictive disorders - sex addiction

Structured interview adapted from the NODS to explore the diagnostic criteria proposed by Carnes et al in 2012

Time frame: Inclusion and 12-month follow-up

Addictive disorders - gambling disorder

Structured interview adapted from the NODS to explore the diagnostic criteria proposed in the third section of the DSM-5 for the Internet gaming disorder

Time frame: Inclusion and 12-month follow-up

Central Contacts

Clémence CABELGUEN, PH

CONTACT

33 2 40 84 61 16 clemence.cabelguen@chu-nantes.fr

Data from ClinicalTrials.gov

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Addictive disorders - eating addiction

Yale Food Addiction Scale (YFAS 2.0)

Time frame: Inclusion and 12-month follow-up

Psychiatric disorders

MINI-S

Time frame: Inclusion and 12-month follow-up

Neuropsychological profile - selective attention

D2-R test (CCT standard score, E% standard score and CC standard score)

Time frame: Inclusion and 12-month follow-up

Neuropsychological profile - short-term and working memory

Digit memory test (standardized scores of numbers of items correctly recalled (direct order, indirect order, ascending order, total), span sizes (direct order, indirect order, ascending order))

Time frame: Inclusion and 12-month follow-up

Neuropsychological profile - inhibition

Stroop test (standardized execution times (naming condition, interference condition), standardized numbers of uncorrected errors (naming condition, interference condition), and standardized interference score)

Time frame: Inclusion and 12-month follow-up

Neuropsychological profile - spontaneous flexibility

Verbal fluency test (standardized scores for the number of words cited and the number of errors, in both conditions (literal and categorical))

Time frame: Inclusion and 12-month follow-up

Neuropsychological profile - planning

Zoo test (total profile score)

Time frame: Inclusion and 12-month follow-up

Psychopathological profile - impulsivity

Urgency, Premeditation (lack of), Perseverance (lack of), Sensation seeking impulsivity behavior scale (UPPS-P) (5 scores)

Time frame: Inclusion and 12-month follow-up

Psychopathological profile - emotional dysregulation

Difficulties in Emotion Regulation Scale (DERS-16) (5 scores and total score)

Time frame: Inclusion and 12-month follow-up

Psychopathological profile - sensorial profile

Sensory profile of Winnie Dunn - adult version (category and raw scores in the 4 quadrants)

Time frame: Inclusion and 12-month follow-up

Psychopathological profile - self-esteem

Rosenberg Self-Esteem Scale (RSES) (total score)

Time frame: Inclusion and 12-month follow-up

Quality of life survey

World Health Organization Quality Of Life (WHOQoL-26) (4 scores)

Time frame: Inclusion and 12-month follow-up

Care received

Effective implementation of treatment with MPH (yes/no) or atomoxetine (yes/no), If no, reasons for not implementing it (for MPH), Care provided (Cognitive remediation / behavioral and cognitive therapy / psychoeducation / other psychosocial intervention (details) / other drug treatment), Reported compliance and misuse for MPH and atomoxetine, Reported compliance for non-drug care, Tolerance: numerical scale from 0 to 10 for the evaluation of the main adverse effects (for MPH and for atomoxetine).

Time frame: 12-month follow-up

Personal and family medical history

List of somatic, psychiatric and addictive disorders for personal history, list of psychiatric and addictive disorders for family history

Time frame: Inclusion

Sociodemographics

Age, gender, level of education, professional status, number of children

Time frame: Inclusion