1. The correlations of serum vitamin D level, serum calcium level and osteoporosis degree with disease severity, treatment response, incidence of Post-Herpes zoster(PHN) and disease prognosis in Herpes zoster(HZ) patients were studied. 2. To investigate the role of inflammation-related factors and immune-related factors in the occurrence and development of HZ mediated by low vitamin D level.
Herpes zoster is a neuropathic disease which induce by the varicella-herpes virus reactivation.and postherpetic neuralgia (PHN) is the most common complication. Currently,the mechanism of herpes zoster still unclearly even though there had much study about it .Vitamin D is an essential vitamin for human body, which has the function of maintaining calcium and phosphorus homeostasis and immune regulation. Vitamin D is a natural antiviral substance, and vitamin D deficiency can affect the body's antiviral ability, thereby promoting varicella-zoster virus(VZV) reactivation, and may promote the development of PHN through continuous neuroinflammation. Therefore, vitamin D level may be related to the occurrence and progression of HZ. this study intends to use an observational cohort study design to investigate the correlation of serum vitamin D level and osteoporosis degree with the severity of the herpes zoster disease, Although we plan to further explore the role of inflammatory state in this process.
Study Type
OBSERVATIONAL
Enrollment
144
Tongji Hospital
Wuhan, Hubei, China
Serum 25-hydroxyvitamin D levels
Vitamin D deficiency: \< 20 nmol/L. Vitamin D deficiency: 20-30 nmol/L. Normal vitamin D: \> 30 nmol/L.
Time frame: herpetic neuralgia <3 month
C-reactive protein
An according to early infection stricture in serum.When CRP\>20mg/l is considered abnormally level .
Time frame: Day 2 in the hospital
Lymphocytes
Lymphocytes is considered an label of virus infection when it outlier.
Time frame: Day 2 in the hospital
Red blood cell distribution width,RDM(fl)
It is a reflects the inhomogeneity of red cell size.
Time frame: Day 2 in the hospital
Red blood cell count,RBC
One of main recording to diagnosis of anemia . nomal mal (4-5.5)×10-12/L. nomal femal (3.5-5.0)×10-12/L.
Time frame: Day 2 in the hospital
Mean red cell volum,MVC
It is a label of red cell size.normal range from 80 to 100fl.
Time frame: Day 2 in the hospital
Creatinine
It is a metabolite of muscle and there are have many reasons induce creatinine rise,such as chronic or acute kidney damage,Medicine side effect.normal range:53-106umol/l.
Time frame: Day 2 in the hospital
Albumin
It is a protein that is found in many animal tissues and serum.The normal range 35-50g/L.
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Time frame: Day 2 in the hospital
Alkaline phosphatase
Alkaline phosphatase (ALP or AKP) is an enzyme that is widely distributed in human liver, bone, intestine, kidney, placenta and other tissues and is excreted from the liver to the bile.normal male: 45\~125U/L；normal female:20\~49岁35\~100U/L
Time frame: Day 2 in the hospital
Uric acid
Uric acid is the end product of purine metabolism. It is a trioxa purine, and its alcohol form is weakly acidic.normal male:150～416μmol/L，normal female:89～357μmolL
Time frame: Day 2 in the hospital
Blood glucose
The production and utilization of blood sugar in normal people are in a state of dynamic balance, maintaining a relatively stable level, which is because the source and route of blood sugar are roughly the same result.Fasting blood-glucose(FBG):4.4\~6.1mmol/L。
Time frame: Day 2 in the hospital
diastolic blood pressure,
An indicator in blood pressure measurement that indicates the pressure of the heart's arterial blood against the vessel walls during diastole. It is usually measured in millimeters of mercury (mmHg).
Time frame: Day 2 in the hospital
systolic blood pressure
A type of blood pressure that refers to the pressure of blood against the artery walls when the heart contracts. It is often used as a measure of cardiovascular health(mmHg).
Time frame: Day 2 in the hospital
total cholesterol
The sum of all cholesterol in the blood, including LDL cholesterol and HDL cholesterol. High levels of total cholesterol may increase the risk of cardiovascular disease.normal range：\<5.18mmol/L（\<200mg/dl）
Time frame: Day 2 in the hospital
triglycerides
Triglyceride (TG) is a constituent of lipids, which is formed by glycerol and three fatty acids. normal range\<1.70mmol/L.
Time frame: Day 2 in the hospital
serum Ca2+ level
Ionic calcium refers to the concentration of calcium ions in the blood, also known as serum calcium. Normal levels of ionic calcium maintain a stable range in the blood, generally 2.1-2.6 mmol/L(or 8.5-10.5 mg/dL).
Time frame: Day 2 in the hospital
Cellular immune indexes C3
Complement C3 can promote phagocytic cells to move to promote phagocytosis, promote B cell proliferation, and have a solubilization effect on soluble immune complex.
Time frame: Day 2 in the hospital
Cellular immune indexes C4
Complement C4 is an important component of the classical activation pathway of complement, which is divided into C4a and C4b. The release of C4a can induce mast cells to release histamine, increase the permeability of blood vessels and cause local exudative inflammation. C4b mainly plays a role in mediating the complement cascade, promoting phagocytosis, participating in preventing the deposition of immune complexes, and neutralizing viruses.
Time frame: Day 2 in the hospital
interleukin(IL)-10
Interleukin-10 is a multi-cellular, multifunctional cytokine that regulates cell growth and differentiation, participates in inflammatory and immune responses, and is a recognized inflammatory and immunosuppressive factor.
Time frame: Day 2 in the hospital
interleukinIL-6
The target cells of IL-6 action are many, including macrophages, hepatocytes, quiescent T cells, activated B cells and plasma cells.
Time frame: Day 2 in the hospital
interleukinIL-8
Interleukin-8, or IL-8 for short, is a cytokine in the family of chemokines. Its role in participating in and regulating the physiological and pathological processes of human reproduction has been confirmed, and one of its mechanisms is to bind to its specific receptors.
Time frame: Day 2 in the hospital
tumor necrosis factor(TNF)-a
TNF-α, also known as cachexin and TNFSF1A, is an adipokine involved in systemic inflammation and is one of the cytokines that stimulate the acute phase response. TNF-α transmits information to the nucleus through specific receptors on the cell membrane, thus producing complex biological activities such as promoting cell proliferation and differentiation, immune regulation, inflammation mediation, and anti-tumor.
Time frame: Day 2 in the hospital
Bone mineral density T value
Bone mineral density T value,present the bone density to predict osteoporosis.
Time frame: Day 2 in the hospital
magnetic resonance imaging
Results of MRI examination,exclude tumor or infection
Time frame: Day 2 in the hospital
cluster of differentiation 4(CD4)+
CD4 cells, refers to the surface of the CD4+T molecule T lymphocytes, is an important immune cell in the human immune system, because the HIV attack object is CD4+T cells, so its detection results on the AIDS treatment effect and the judgment of the patient's immune function has an important role.
Time frame: Day 2 in the hospital
cluster of differentiation 8(CD8)+
CD8+T cells generally refer to cytotoxic T lymphocytes. Cytotoxic T lymphocytes (CTL), a subdivision of white blood cells, are specific T cells that secrete various cytokines to participate in immune function.
Time frame: Day 2 in the hospital
numeric rating scale(NRS)
The NRS pain Score is an exponential scale that uses 0 to 10 to represent different levels of pain, 0 being painless and 10 being severe, and asks the patient how bad the pain is, or to circle a number that best represents their pain.
Time frame: Day 2 in the hospital
numeric rating scale(NRS)
The NRS pain Score is an exponential scale that uses 0 to 10 to represent different levels of pain, 0 being painless and 10 being severe, and asks the patient how bad the pain is, or to circle a number that best represents their pain.
Time frame: After the therapy in hospital
numeric rating scale(NRS)
The NRS pain Score is an exponential scale that uses 0 to 10 to represent different levels of pain, 0 being painless and 10 being severe, and asks the patient how bad the pain is, or to circle a number that best represents their pain.
Time frame: After the therapy 1 month
numeric rating scale(NRS)
The NRS pain Score is an exponential scale that uses 0 to 10 to represent different levels of pain, 0 being painless and 10 being severe, and asks the patient how bad the pain is, or to circle a number that best represents their pain.
Time frame: After the therapy 2 month
numeric rating scale(NRS)
The NRS pain Score is an exponential scale that uses 0 to 10 to represent different levels of pain, 0 being painless and 10 being severe, and asks the patient how bad the pain is, or to circle a number that best represents their pain.
Time frame: After the therapy 3 month
DN4
A table of pain assesment that mainly about neuropathic pain.
Time frame: Day 2 in the hospital
DN4
A table of pain assesment that mainly about neuropathic pain.
Time frame: After therapy in hospital
DN4
A table of pain assesment that mainly about neuropathic pain.
Time frame: After therapy 1 month
DN4
A table of pain assesment that mainly about neuropathic pain.
Time frame: After therapy 2 month
DN4
A table of pain assesment that mainly about neuropathic pain.
Time frame: After therapy 3 month