PPIO-006 Primary Tumor Resection for IVa NSCLC

Daping Hospital and the Research Institute of Surgery of the Third Military Medical University223 enrolled

Overview

The goal of this mutli-center observational study is toinvestigate the impact of primary tumor resection (PTR) on the long-term survival of patients with non-small-cell lung cancer (NSCLC) and dry pleural dissemination (DPD). The main question it aims to answer is: whether primary tumor resection improve long-term survival of NSCLC patients with dry pleural dissemination.

Non-small-cell lung cancer (NSCLC) patients with dry pleural dissemination have poor survival rates and are generally contraindicated for surgery. Previous single-center retrospective studies have suggested that these patients may benefit from primary tumor resection (PTR). However, the evidence supporting PTR is still limited, especially in the era of targeted therapy. This study aimed to investigate the impact of PTR on the long-term survival of patients with NSCLC and DPD.

Study Type

OBSERVATIONAL

Enrollment

223

Conditions

Non-small-cell Lung Cancer (NSCLC)

Interventions

Primary tumor resection or notPROCEDURE

For patients with non-small-cell lung cancer (NSCLC) and dry pleural dissemination, surgical decisions to perform exploratory thoracotomy only or primary tumor resection with wedge resection, segmentectomy, or lobectomy were based on surgeon experience and patient preference.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: (1) pathologically confirmed primary NSCLC with malignant pleural dissemination, (2) no preoperative treatment, (3) age 80 years or younger, (4) clinicopathologic data and follow-up results were complete. Exclusion Criteria: (1) pleural effusion, contralateral lung metastasis or distant metastasis revealed preoperatively, and (2) with a history of other malignant disease.

Locations (1)

Army Medical Center of the People's Liberation Army

Chongqing, Chongqing Municipality, China

Outcomes

Primary Outcomes

Disease-specific survival (DSS)

The duration from the day of surgery to the the last follow-up visit or to death specifically caused by NSCLC.

Time frame: Up to 8 years

Secondary Outcomes

Progression-free survival (PFS)

The duration of survival with no evidence of progression of the disease.

Time frame: Up to 8 years

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.