Study of Intra-articular Allocetra in Knee Osteoarthritis

Inclusion Criteria: 1. Age 45 - 80 years. 2. Chronic osteoarthritis of index knee with knee-related joint pain 3. Radiographic evidence of knee osteoarthritis of K-L Grade 2 or 3 in the index knee. 4. Knee pain assessed daily over a period of 7 days during the screening period and following wash-out of pain medications 5. Patients with chronic knee pain for at least 3 months who have failed to respond adequately to conventional therapy. 6. Willing to abstain from other intra-articular treatments and adhere to the protocol restrictions for concomitant medications and therapies during the study. 7. Women of childbearing potential and all men must agree to use 2 methods of an adequate contraception prior to study entry and for the duration of study participation through 4 weeks following IP administration. Exclusion Criteria: 1. Wheelchair bound. 2. Immunosuppressive therapy 3. Any known current or prior tumor of the index knee. 4. Any known history or current intra-articular or osseous infection of the index knee. 5. Any evidence of clinically significant active infection 6. Any known history of inflammatory arthropathy or crystal-deposition arthropathy 7. Any known severe systemic cartilage and/or bone disorder, such as, but not limited to, chondrodysplasia, osteogenesis imperfecta. 8. Body Mass Index (BMI) \>40. 9. Any major surgical cartilage treatment within 6 months 10. Any ligamentous repair or malalignment correction in the index knee within 6 months 11. Major injury to the index knee, such as torn ligament or severe sprain within 6 months 12. Clinically relevant knee instability of the index knee 13. Severe hip osteoarthritis ipsilateral to the index knee. 14. Clinically significant widespread pain syndromes, e.g., fibromyalgia, long COVID syndrome. 15. Known coagulopathy, or use of anticoagulation medication or antiaggregant medication;. 16. certain tumors, severe cardiac, respiratory or hematologic diseases as defined in the protocol