Dexamethasone vs. Dexmedetomidine for ESPB in Pain Management After Spine Surgery

Phase 4RecruitingNCT06233617

Poznan University of Medical Sciences90 enrolled

Overview

Effect of perineurial dexamethasone and dexmedetomidine on erector spinal plane block duration for spine surgery.

This study is proposed to explore the effect of perineurial Dexamethasone and Dexmedetomidine on erector spinal plane block duration for spine surgery. After spine surgery, patients need good analgesia. Peripheral nerve blocks have provided a safe, effective method to control early postoperative pain when symptoms are most severe. The safety of local anaesthesia is essential due to the much lower toxicity threshold of local anaesthetics. An effective adjuvant, such as Dexamethasone or Dexmedetomidine, could allow for a higher dilution of local anaesthetics while maintaining and enhancing their analgesic effect. There is considerable research where intravenous and perineural dexamethasone and Dexmedetomidine use have been compared in adults. However, there is a massive lack of research regarding spine surgery and the Erector Spinae Plane Block. In this study, investigators compare perineural Dexamethasone and Dexmedetomidine. The investigator aims to find a dexamethasone or dexmedetomidine that covers the need for good pain relief and fast recovery postoperatively.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Spinal Fusion Spine Disease Spinal Stenosis Erector Spinae Plane Block

Interventions

0.9% Sodium Chloride InjectionDRUG

biliteral administration of 20ml of 0,2% ropivacaine + 2ml 0.9% sodium chloride for the erector spine plane block

Dexamethasone 4 Mg/mL Injectable SolutionDRUG

biliteral administration of 20ml of 0,2% ropivacaine with 4mg Dexamethasone for the erector spine plane block

Dexmedetomidine injectionDRUG

biliteral administration of 20ml of 0,2% ropivacaine with 50ug Dexmedetomidine for the erector spine plane block

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients undergoing primary posterior lumbar decompression and stabilization with instrumentation involving multi-levels in the lumbar region, * aged \>18 years and \<100 years * ASA physical status 1, 2 or 3. Exclusion Criteria: * refuse to participate, * history of opioid abuse, * infection of the puncture site, * aged \<18 years and \>100 years * ASA 4 and 5

Locations (1)

Poznan University of Medical Sciences

Poznan, Poznań, Poland

RECRUITING

Outcomes

Primary Outcomes

first need of opiate

Time after surgery when the patient needs opiate for the first time

Time frame: 48 hours