Association Between Pre-op Non-Selective Beta-Blockers and Hepatocellular Carcinoma Recurrence Post-Liver Transplant

Asan Medical Center2,092 enrolled

Overview

The goal of this observational study is to investigate the effect of non-selective beta-blocker (NSBB) on the recurrence of hepatocellular carcinoma (HCC) following liver transplantation in patients who underwent liver transplantation (LT) for treating hepatocellular carcinoma. The main question\[s\] it aims to answer are: * Is the usage of non-selective beta-blocker associated with decreased recurrence of hepatocellular carcinoma following liver transplantation? * Is the usage of non-selective beta-blocker associated with all-cause mortality following liver transplantation? Researchers will compare the NSBB group, including patients who received non-selective beta-blocker therapy for at least 30 consecutive days within 3 months prior to liver transplantation more than 30 days prior, with the control group to to see if non-selective beta-blocker treatment is associated with decreased recurrence of hepatocellular carcinoma following liver transplantation.

Study Type

OBSERVATIONAL

Enrollment

2,092

Conditions

Hepatocellular Carcinoma Recurrent Hepatocellular Carcinoma

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients * Underwent liver transplantation for treating hepatocellular carcinoma * Between Jan. 2008 - May. 2022 Exclusion Criteria: * Pediatric patients (Age under 18 years) * Re-transplantation * Multi-organ transplantation

Outcomes

Primary Outcomes

Kaplan-Meier survival analysis of HCC recurrence at 5-year follow-up

HCC recurrence, which was diagnosed based on pathological or radiographic evidence of new lesions consistent with HCC, and recurrence-free survival was collected and compared using Kaplan-Meier survival analysis.

Time frame: Baseline and 5-year follow-up

Multivariate Cox regression analysis of HCC recurrence at 5-year follow-up

Multivariate Cox regression analysis was performed to identify the risk factors for HCC recurrence.

Time frame: Baseline and 5-year follow-up

Secondary Outcomes

Kaplan-Meier survival analysis of overall survival at 5-year follow-up

Overall survival was collected and compared using Kaplan-Meier survival analysis.

Time frame: Baseline and 5-year follow-up

Multivariate Cox regression analysis of overall survival at 5-year follow-up

Multivariate Cox regression analysis was performed to identify the risk factors for overall mortality.

Time frame: Baseline and 5-year follow-up