The goal of this feasibility study is to evaluate the safety and efficacy of the Renal Stimulation (RNS) by Direct Wire Pacing, during Renal Denervation (RDN) procedure in patient candidate for renal denervation with the ParadiseTM System. The main questions it aims to answer are: * Is the RNS before RDN a straightforward method, allowing quantification of the renal sympathetic traffic? * Does the RNS increase blood pressure (SBP), and is this increase significantly blunted after RDN? * Does the 3-month 24h SBP decrease correlated with the RNS-induced SBP change before RDN? * Can the difference between RNS-induced SBP rise before and after RDN be used as a procedural endpoint for RDN? Participants will be asked for their agreement to conduct an RNS before and after the RDN. No additional experimental procedure will be added to the standard of care.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
10
Renal Denervation procedure as per hospital routine practice
prevalence of occurrence of adverse events
safety of the renal nerves stimulation performed by Direct Wire Pacing technique during renal denervation procedure
Time frame: Three month after procedure
efficacy on Systolic Blood Pressure change to be measured with a blood pressure monitor
efficacy of the renal nerves stimulation performed by Direct Wire Pacing technique during renal denervation procedure
Time frame: Three month after procedure
Impact on Systolic Blood Pressure
Investigate the impact of the renal denervation in the Renal Nerves Stimulation induced Systolic Blood Pressure change.
Time frame: Three month after procedure
Systolic Blood Pressure as response prediction tool
Investigate whether Renal Nerves Stimulation induced Systolic Blood Pressure change before Renal Denervation could be a reliable tool to predict mid-term Renal Denervation response
Time frame: Three month after procedure
Systolic Blood Pressure variation as response prediction tool
Investigate whether difference in Renal Nerves Stimulation-induced Systolic Blood Pressure change before and after Renal Denervation could be a reliable tool to predict mid-term Renal Denervation
Time frame: Three month after procedure
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