Exploring 8-iso Prostaglandin F2α and Adenosine Deaminase Levels in Periodontal Health and Disease

Eda Cetin Ozdemir80 enrolled

Overview

This study aims to assess the diagnostic potential of gingival crevicular fluid (GCF) biomarkers, specifically 8-iso Prostaglandin F2α (8-iso-PGF2α) and adenosine deaminase (ADA), in evaluating periodontal health and disease conditions.

Conducted as a single-blind, cross-sectional investigation, this study comprised 26 individuals categorized as periodontally healthy, 27 with gingivitis, and 27 diagnosed with periodontitis. The participant pool included individuals with various periodontal concerns who were referred to the Department of Periodontology Clinic at Kahramanmaraş Sütçü İmam University. The classification of periodontal health, gingivitis, and chronic periodontitis adhered to the 2018 criteria outlined by the European Federation of Periodontology

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Periodontal Diseases

Interventions

8-iso Prostaglandin F2α and Adenosine DeaminaseDIAGNOSTIC_TEST

We took gingival crevicular fluid samples from patients who applied to our clinic and evaluated the -iso Prostaglandin F2α and Adenosine Deaminase levels in the samples.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients having more than 20 teeth, minimum age 18, maximum age 65 Exclusion Criteria: * Patients with systemic disease, Active smokers, Pregnant women, individuals with a history of orthodontic treatment, or those who had undergone periodontal treatment, regardless of whether it was surgical or non-surgical (within the last one year),

Locations (1)

Kahramanmaraş Sütçü İmam University

Kahramanmaraş, Oniki Şubat, Turkey (Türkiye)

Outcomes

Primary Outcomes

Change in 8-iso Prostaglandin F2α and Adenosine Deaminase scores in periodontal disease

We expect 8-iso Prostaglandin F2α and Adenosine Deaminase scores to increase in periodontal disease.

Time frame: 2023

Data from ClinicalTrials.gov

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