The goal of this clinical trial is to evaluate, if a change in dosing strategy in oral iron supplementation from leads to an improvement of iron absorption and consequently a faster therapy in patients with iron deficiency. The main question the study aims to answer is: Does a treatment effect (measured by change in hemoglobin after 12 weeks of treatment) exist between daily oral iron supplementation and interval administration (every second day)? Participants will receive oral iron supplementation every second day with double the standard dose (intervention group). Researchers will compare this group with the active control group, that receives oral iron supplementation every day with the standard dose. Participants will present for three patient visits (at baseline, after 6 and after 12 weeks of treatment).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
29
Interval Dosing Strategy (Administration of oral iron every second day with double the standard dose instead of every day standard dose)
Luzerner Kantonsspital
Lucerne, Switzerland
Change of Hemoglobin after 12 weeks
Change (from baseline before treatment) of hemoglobin after 12 weeks of oral iron supplementation
Time frame: 12 weeks
Proportion of participants achieving treatment goal
Proportion of participants achieving either increase of hemoglobin (\>20 g/l), normalization of hemoglobin (women \>120 g/l, pregnant women \>110 g/l and men \>130 g/l) after 12 weeks of oral iron supplementation
Time frame: 12 weeks
Change of iron parameters from baseline
Change of iron parameters from baseline compared to after treatment of 12 weeks
Time frame: 12 weeks
Side effects
Side effects during treatment with oral iron supplementation in both groups (intervention and active control)
Time frame: 12 weeks
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