Novel Brominated and Organophosphate Flame Retardants and Type 2 Diabetes

Inclusion Criteria: Group of Type 2 diabetes patients: 1. age 18 \~ 75 years old; 2. type 2 diabetes patients diagnosed in the First Affiliated Hospital of Shandong First Medical University (Qianfoshan Hospital of Shandong Province) , HBA1C ≥7.0% and \<10.5% ; 3. patients signed informed consent. Control Group: 1. age 18 \~ 75 years old; 2. healthy population recruited from the First Affiliated Hospital of Shandong First Medical University (Qianfoshan Hospital of Shandong Province) ; 3. living in the monitoring area for more than 6 months within 12 months; 4. normal thyroid function and no history of thyroid cancer were needed in the control group; 5. Fasting Blood Glucose level of 0.7 mmol/l was needed in the Control Group of Type 2 diabetes Mellitus Without History of diabetes; 6. patients with informed consent. Exclusion Criteria: * Group of Type 2 diabetes: 1. pregnant, lactating women, patients with acute cardiac cerebrovascular disease; 2. patients with severe liver and Renal Impairment (related laboratory tests more than 2 times the normal) ; 3. patients with Type 1 diabetes; 4. participants in other clinical trials within 3 months; 5. patients with malignant tumors. 6. has the disease and so on serious anemia, is not suitable to carry on the patient which the blood draws the test. Control Group: 1. patients with serious heart, liver or kidney disease; 2. patients with iodine or Thyroid hormone; 3. patients with confirmed malignant tumor; 4. pregnant women or those who have recently taken contraception or estrogen.