Acute Pancreatitis : Comparison of Various Scores in Predicting Severity and Outcome

Sohag University50 enrolled

Overview

The study will make a comparison between Various severity scoring systems that has been designed to assess the severity and predict prognosis in acute pancreatitis

the study will evaluate the relationship between homeostatic model assessment of insulin resistance , bedside index of severity score and the harmless acute pancreatitis score and prognosis of acute pancreatitis ,will compare of these scores in predicting severity of acute pancreatitis and will compare of these scores in predicting outcome of acute pancreatitis.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Acute Pancreatitis

Interventions

laboratory investigation and ImagingDIAGNOSTIC_TEST

laboratory parameters (white blood cell count,neutrophil count, lymphocyte count, hemoglobin level, platelet level, red cell distribution width (RDW) level, hematocrit (HCT), renal function, hepatic function, electrolytes, arterial blood gas, HOMA-IR) will be assessed and imaging: Abdominal ultrasonography, Abdominal CT or MRI if needed

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Any patient with 18 years or above and met criteria for diagnosis of acute pancreatitis will be eligible for the study. Exclusion Criteria: \-

Outcomes

Primary Outcomes

Comparison of various scores in predicting severity and outcome in patients with acute pancreatitis. 1.Homeostatic model assessment of insulin resistance. 2.The harmless acute pancreatitis score.

1. Homeostatic model assessment of insulin resistance it measure severity of insulin resistance, there is an association between insulin resistance and severity of acute pancreatitis. It is defined as fasting glucose (mmol/L) × fasting insulin (μmol/L)/22.5\] or \[fasting glucose (mg/dL) × fasting insulin (μmol/L) Reference index levels is ≤ 2. If index ˃ 2 indicate presence of insulin resistance 2. The harmless acute pancreatitis score Harmless acute pancreatitis score contains three parameters - blood urea nitrogen, levels of serum creatinine and haematocrit . The patient is classified as harmless acute pancreatitis score negative (-) if they have blood urea nitrogen \<25 mg/dL, serum creatinine levels \< 2 mg/dL, and haematocrit levels of \<43% for males and \<39.6% for females at the time of admission. The patient is considered positive (+) if any one of the above parameters is positive.

Time frame: within 18 months

Data from ClinicalTrials.gov

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