Multi-institutional Analysis of Survival and Recurrence Patterns of Different Pathological Regression Types After Neoadjuvant Chemoradiotherapy or Radiotherapy for Esophageal Squamous Cell Carcinoma

Tianjin Medical University Cancer Institute and Hospital582 enrolled

Overview

The goal of this multicenter retrospective cohort study is to evaluate the impact of different pathological regression types on survival and recurrence patterns, with a particular focus on ypT0N+ patients in patients with esophageal squamous cell carcinoma. The main questions it aims to answer are the survival and recurrence patterns among the different pathological regression types in patients with esophageal squamous cell carcinoma after neoadjuvant chemoradiotherapy.

Study Type

OBSERVATIONAL

Enrollment

582

Conditions

Esophageal Squamous Cell Carcinoma

Interventions

non-interventionOTHER

non-intervention

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * histologically confirmed potentially resectable ESCC, clinical stage T1-4N0-1M0 (stage I-III) according to the American Joint Committee on Cancer 6th edition staging criteria. Exclusion Criteria: * incomplete surgical resection, two-dimensional radiotherapy, and incomplete clinical data.

Outcomes

Primary Outcomes

Overall survival

the time from the date of surgery to death or last follow-up (2023.01.31)

Time frame: From date of surgery until the date of death from any cause or last follow-up, assessed up to 10 years.