Vitamin D Serum Levels in Monosymptomatic Enuretic and Non Enuretic Children

Ain Shams University60 enrolled

Overview

We are group of researchers interested in causes and management of nocturnal enuresis, we embarked on this research on 2020 and we reached promising results regarding the role of vitamin D serum level in etiology and management of monosymptomatic enuresis.

this research was conducted as a comparative study regarding serum vitamin D levels in monosymptomatic enuretic and non enuretic children, also we compared urine osmolality and nocturnal polyuria in both groups and we found that low vitamin D levels are correlated with low nocturnal urine osmolality and increased incidence of nocturnal polyuria

Study Type

OBSERVATIONAL

Enrollment

Conditions

Nocturnal Enuresis

Interventions

serum vitamin DDIAGNOSTIC_TEST

blood sample for serum vitamin D level Vitamin D serum level was measures using the ELISA technique. The Cal Biotech Vitamin D Kit (Mannheim, Germany) was used, which is a solid phase enzyme linked immunoassay (ELISA), based on the principal of competitive binding. Vitamin D deficiency was defined as serum Vit. D below 20 ng/ml.

urine osmolalityDIAGNOSTIC_TEST

nocturnal urine osmolality: Clear instructions for mothers were to let the child void before sleep and every two hours till 8 am. Short intervals were meant to avoid enuretic episodes during calculation of nocturnal urine volume, and if occurred it mandates the repeat of chart on another day. Nocturnal urine collected over the night was tested for osmolality, it was measured in mOsm/kg.

Frequency volume chartOTHER

Eligibility

Sex: ALLMin age: 5 YearsMax age: 15 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with PMNE. * which was defined as bedwetting frequency of 3 or more nights per week for at least 2 weeks of observation. * Didn't receive any previous treatment for enuresis. Exclusion Criteria: * Patients with non-monosymptomatic enuresis (associated with storage and/or voiding symptoms). -Patients with anatomical abnormalities (Meatal stenosis, Hypospadias, Epispadias, etc.). * Patients with neurological diseases. * Patients with Renal impairment. * Patient with previous pelvic, urological or brain and spinal cord surgery. * Patients with chronic constipation and irritable bowel habits. * Patients with active urinary tract infection. * Patients who are on vitamin D supplements.

Locations (1)

Cairo

Cairo, Egypt

Outcomes

Primary Outcomes

Vitamin D level

low vitamin d levels in enuretic group

Time frame: through study completion, average 1 year.

Secondary Outcomes

nocturnal polyuria

frequency volume chart idobtained

Time frame: through study completion, average 1 year.

low nocturnal urine osmolality

nocturnal urine osmolality

Time frame: through study completion, average 1 year.

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.