The goal of this randomized trial is to compare bladder cancer patient experiences taking prophylactic anticoagulation at home after surgery to remove their bladder. The main questions it aims to answer are: * Are patients equally adherent to apixaban as they are enoxaparin? Why or why not? * Do patients prefer apixaban or enoxaparin? * What is the typical patient cost to take apixaban vs enoxaparin after surgery? Participants will be randomized to receive a prescription for either enoxaparin or apixaban which they will then fill themselves and self-administer at home until post-operative day 30. They will receive phone calls from study coordinators at days 30 and 90 to complete questionaries over the phone to assess trial outcomes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
126
Participants will be randomized to receive a prescription for prophylactic apixaban
Participants will be randomized to receive a prescription for prophylactic enoxaparin
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States
Adherence
proportion of days covered
Time frame: Day of discharge to post-operative day 30
Cost
patient out of pocket cost to fill their VTE prophylaxis prescription
Time frame: Day of discharge to post operative day 90
Satisfaction as measured by 2. National Institute of Health (NIH) Patient-Reported Outcomes Measurement Information System (PROMIS) Medication Adherence Scale (PMAS)
patient satisfaction with their VTE prophylaxis drug
Time frame: Day of discharge to post-operative day 30
Reasons for non-adherence
patient-reported issues with adherence
Time frame: Day of discharge to post-operative day 30
VTE rate
rate of venous thromboembolism events
Time frame: Day of discharge to post-operative day 90
Bleeding rate
rate of major and minor bleeding events
Time frame: Day of discharge to post-operative day 90
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