Comparison of Outcomes Between Intraosseous Femoral and Tibial Injection in Simultaneous Bilateral Total Knee Arthroplasty Patients

Department of Medical Services Ministry of Public Health of Thailand20 enrolled

Overview

In patients with osteoarthritis of the knee whose pain cannot be relieved by conservative treatment, total knee arthroplasty (TKA) is the operation that increases the quality of life for the patient. Pain management after total knee arthroplasty TKA is an important consideration to improve patient outcomes and reduce length of stay. Periarticular injections of the knee are one of the techniques used to reduce pain after surgery. Studies have shown that compared to other methods of pain relief, they are effective and safe. At present, no studies to compare between multimodal intraosseous femoral injection \& multimodal intraosseous tibial injection in Simultaneous Bilateral TKA patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Pain, Postoperative

Interventions

Eligibility

Sex: ALLMin age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who will undergo bilateral Total knee Replacement due to osteoarthritis of both knees * Used of a cemented, PS design TKA surgery. * Able to give informed consent Exclusion Criteria: * Revision TKA * History of previous knee or hip surgery * History of allergic reaction or side effects to the drug that will be used in the experiment * Underlying diseases of chronic kidney disease or chronic liver disease (Child Pugh B or C) * Pregnancy * History of coagulopathy or abnormal blood coagulation profile(INR \>1.4 or aPTT ratio \> 1.4) * History of platelet dysfunction or platelet count \< 140,0000/mm3 * History of Thromboembolism * Use of Anticoagulants.

Outcomes

Primary Outcomes

Pain score (Visual analog scale)

Visual analog scale (VAS) score from 0-10(0 was no pain, 10 was worst pain ) between multimodal intraosseous femoral injection \& multimodal intraosseous tibial injection

Time frame: at 12 hours, 24 hours, 48 hours and 2 weeks after surgery

Secondary Outcomes

Amount of painkillers used

Time frame: up to 24 hours after surgery

Post operative blood loss

Time frame: intraoperative and up to 48 hours postoperatively (include intraoperative and drain)

Knee and Osteoarthritis Outcome Score (KOOS)

minimum and maximum values(0-100), higher scores mean a better outcome.

Time frame: post operative 2 weeks

knee range of motion

Time frame: post operative 2 weeks

Side effects and complications

Time frame: intraoperative to post operative 2weeks

Length of hospital stay

Length of hospital stay record in number of days

Time frame: Admit to discharge date (up to 7 days)