Myomectomy was preferably applied in females with reproductive requirements, which could be achieved by transumbilical laparoendoscopic single-site surgery (TU-LESS) or multi-port laparoscopic surgery (MPLS). Power morcellation used in MPLS was correlated with unidentified risk of tumor dissemination, especially in cases with accidental surgical findings of uterine sarcoma or leiomyosarcoma. Moreover, TU-LESS was reported to exceed MPLS in fast recovery. Therefore, the aim of this prospective cohort study is to compare the effectiveness of fast recovery and relative risk of tumor dissemination between TU-LESS and MPLS in myomectomy for the treatment of uterine fibroids.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
5,000
TU-LESS group will receive TU-LESS for myomectomy; MPLS group will receive MPLS for myomectomy
Patients with uterine who plan to receive MPLS for myomectomy
West China Second University Hospital
Chengdu, Sichuan, China
Duration of hospital stay after surgery
The number of days between myomectomy and the day of hospital discharge.
Time frame: From enrollment to 1 month after receiving myomectomy
VAS score at 4, 8, 12, 16, 20, 24 hours after myomectomy
The visual analogue score at 4, 8, 12, 16, 20, 24 hours after myomectomy will be collected through questionnaire.
Time frame: From enrollment to 24 hours after myomectomy
Time between myomectomy and exhaustion
The exact time between myomectomy and exhaustion will be collected during wards round by directly asking the patients.
Time frame: From enrollment to 1 week after myomectomy.
Time of surgery
The time of surgery (from superficial incision to the end of umbilical suturing in experimental group and end of incision suturing in control group) will be collected during surgery.
Time frame: From enrollment to 1 day after myomectomy.
Volume of bleeding during myomectomy
The exact volume of bleeding during myomectomy in both experimental and control group will be collected during surgery.
Time frame: From enrollment to 1 day after myomectomy.
Number of uterine fibroids resected during surgery.
The exact number of uterine fibroids resected during myomectomy in both experimental and control group will be collected during surgery.
Time frame: From enrollment to 1 day after myomectomy.
Pregnancy outcome
Whether the patient had pregnancy within 2 years after myomectomy. The information will be collected through online questionnaire and telephone.
Time frame: From enrollment to 2 years after myomectomy
Occurrence of pelvic and abdominal metastasis after myomectomy in cases with accidental uterine malignancy
According to epidemiology data, a fraction of patients with primarily identified uterine fibroids will be pathologically diagnosed with uterine malignancy like uterine sarcoma after surgery. Whether the patients who were finally diagnosed with uterine malignancy based pathology developed abdominal or pelvic metastasis will be collected by telephone follow-up.
Time frame: From enrollment to 2 years after receiving myomectomy
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