Liver Resection for Patients With Hepatocellular Carcinoma and Clinically Significant Portal Hypertension

Tang-Du Hospital3,000 enrolled

Overview

Clinically significant portal hypertension limits the therapeutic options for hepatocellular carcinoma (HCC), which is closely associated with patient prognosis. HCC patients with CPSH are heterogeneous and treatment allocation remains controversial. The aim of this study was to compare the survival benefits of liver resection (LR) and transarterial chemoembolisation (TACE) in these populations.

Study Type

OBSERVATIONAL

Enrollment

3,000

Conditions

Hepatic Carcinoma

Interventions

transarterial chemoembolisationPROCEDURE

During transarterial chemoembolisation（TACE）, a vascular catheter was selectively inserted into the tumour-feeding artery with an injection containing a mixture of doxorubicin (10-50 mg) and lipiodol (2-20 mL), followed by embolisation using gelatin sponge particles. TACE was repeated when residual viable tumours were confirmed or new lesions developed in patients with adequate liver function

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * HCC patients treated conventional liver resection or transarterial chemoembolisation Exclusion Criteria: * (1) presence of types III/IV portal vein tumour thrombosis (PVTT), hepatic artery, biliary duct or inferior vena cava invasion; (2) presence of extrahepatic spread (EHS); (3) underwent previous treatments; (4) Eastern Cooperative Oncology Group Performance Status (ECOG-PS) \>1; (5) diffuse tumor nodules; (6) combined with other tumours or severe cardiac, cerebral, and renal insufficiency; (7) non-Clinically significant portal hypertension（CSPH）, and (8) absence of baseline information

Locations (2)

Tangdu hospital

Xi'an, Shaanxi, China

Xijing hospital

Xi'an, Shaanxi, China

Outcomes

Primary Outcomes

overall survival rate

Time frame: 5 year

Data from ClinicalTrials.gov

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