Ibuprofen and Biomarkers of Acute Kidney Injury After Running in the Heat

Inclusion Criteria: * Physically active (engage in at least 150 minutes of moderate to vigorous intensity exercise per week) * between the ages of 18 and 45 * Able to run continuously for at least 60 minutes * Able to speak and read English. Exclusion Criteria: * Non-English speakers, prisoners, pregnant women, or persons requiring a LAR * Previous history of heat stroke or heat illness * Currently experiencing a sunburn or other burn injury * Have repeated exposure to heat, such as hot baths, sauna, or travel to a hot environment * Has resided in a hot climate within 2 months prior to the trial * Answered "yes" to at least one question on the physical activity readiness questionnaire * Shows signs or symptoms of or are known to have cardiovascular, renal, metabolic, or pulmonary disease as determined by a health questionnaire * Are a current smoker * History of regular gastrointestinal distress * Known history of stomach ulcers or taking blood thinning medication * Known allergy to ibuprofen * Have a resting blood pressure greater than 140 systolic or 90 diastolic * Do not engage in at least 150 minutes of moderate to vigorous intensity exercise per week.