Endocytoscopy of Upper Gastrointestinal Tract in Acute Graft-versus-host Disease: a Pilot Study

Ruijin Hospital14 enrolled

Overview

The goal of this clinical trial is to test the assess the diagnostic effectiveness of endocytoscopy in patients with underlying UGI aGvHD. The main question it aims to answer is: the effectiveness of ECS for diagnosing UGI aGvHD. Participants will undergo endoscopy, endocytoscopic evaluation and biopsy simultaneously. If there is a comparison group: Researchers will compare endoscopic, endocytoscopic and pathologic findings of these patients.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Endocytoscopy

Interventions

ECS GroupPROCEDURE

Patients underwent endoscopic and endocytoscopic evaluations.

Eligibility

Sex: ALLMin age: 14 Years

Medical Language ↔ Plain English

Inclusion Criteria: * aged ≥ 14 years * developed UGI symptoms within first three months after engraftment or during the tapering of immunosuppressive agents Exclusion Criteria: * \< 14 year * with underlying gastrointestinal disease before allo-HSCT * incomplete medical information

Locations (1)

Ye Zhao

Shanghai, China

Outcomes

Primary Outcomes

the effectiveness of endocytoscopy for diagnosing UGI aGvHD

the percentage of esophageal, gastric, and duodenal UGI aGvHD diagnosed by endocytoscopy

Time frame: three months

Data from ClinicalTrials.gov

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