The present multicentre retrospective cohort study aimed to investigate the association between intraoperative administration of dexmedetomidine and postoperative mortality in hospitals. The investigators set out to test the hypothesis that perioperative dexmedetomidine use, as an adjunct to general anesthesia, diminishes postoperative mortality in hospitals across all categories of surgical patients.
Study Type
OBSERVATIONAL
Enrollment
518,043
whether intraoperative dexmedetomidine was administered adjunct to propofol for patients undergoing surgeries under general anaesthesia
in-hospital all-cause mortality
in-hospital deaths or discharged to hospice (or home)
Time frame: from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 1 year
length of postoperative hospital stay
in days
Time frame: from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 1 year
admission to the intensive care unit (ICU)
unplanned admissions
Time frame: from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 1 year
adverse events after surgery
severe stroke, the necessity for renal replacement therapy (RRT), myocardial infarction, ventilator-associated pneumonia (VAP), acute respiratory distress syndrome (ARDS), unplanned reoperation due to postoperative complications, sepsis, and multi-organ dysfunctions (MODs), if any
Time frame: from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 1 year
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