To investigate the association between the the early administration of L-Arginine after CPB-assisted cardiac surgery and the incidence of CS-AKI in adult patients. To test if it can reduce the incidence of post-operative AKI.
Study Type
OBSERVATIONAL
Enrollment
7,000
Postoperative administration of L-Arginine hydrochloride before incidence of CS-AKI
Xijing Hospital
Xi'an, Shaanxi, China
RECRUITINGincidence of postoperative AKI
Serum Creatinine Criteria: Increase in Serum Creatinine: An absolute increase in serum creatinine of 0.3 mg/dL (26.5 µmol/L) within 48 hours. OR a percentage increase in serum creatinine of ≥50% within 7 days. These criteria are relative to the baseline creatinine level, which is usually the recent preadmission value. Urine Output Criteria: Oliguria, defined as a urine output \<0.5 mL/kg/h for more than 6 hours. OR anuria, defined as a urine output \<100 mL in 24 hours.
Time frame: from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 30 days
Renal failure
KDIGO defined AKI stage ≥ 2, or if dialysis is required for newly developed conditions KDIGO classifies AKI into three stages based on the severity: Stage 2: Increase in serum creatinine of 2.0 to 2.9 times baseline OR Urine output \<0.5 mL/kg/h for ≥12 hours. Stage 3: Increase in serum creatinine of 3.0 times baseline OR Increase in serum creatinine to ≥4.0 mg/dL OR Initiation of renal replacement therapy (RRT) OR Urine output \<0.3 mL/kg/h for ≥24 hours OR anuria for ≥12 hours.
Time frame: from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 30 days
in-hospital mortality
all-cause postoperative deaths observed
Time frame: from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 30 days
length of in-hospital stay
postoperative stay until discharge or death
Time frame: from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 30 days
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