Feasibility, Acceptability, and Effectiveness of an Individualized Plant-based (iPLANT) Diet Plan in Colorectal Cancer: Mixed Method Embedded Design

Change from baseline in mean Patient-Generated Subjective Global Assessment score at 12 weeks

The PG-SGA score is derived from components of weight history, food intake, nutritional impact symptoms, and activity function. The possible scores range from 0 (well-nourished) to 37 (worst possible malnourished)

Time frame: Change from baseline to week 12

Change from baseline in mean skeletal muscle Index, body fat mass, extracellular water ratio, phase angle at 12 weeks

The higher values of skeletal muscle index and phase angle indicate lower risk of malnutrition, whereas higher reading of extracellular water ratio indicates higher risk of malnutrition. Higher body fat mass indicates higher adiposity level.

Time frame: Change from baseline to week 12

Change from baseline in mean mid arm muscle area at 12 weeks

Respondents develop cachexia if values are less than 32 (male) and 18 (female)

Time frame: Change from baseline to week 12

Change from baseline in mean handgrip strength at 12 weeks

Respondents have weak muscle if the values are 27 or less (male) and 16 or less (female)

Time frame: Change from baseline to week 12

Change from baseline in mean quality of Life at 12 weeks

EORTC QLQ-CR29 is a validated tool to measure the functional scales and symptomatic level of colorectal cancer that resulted from disease or treatment factors. Possible scores range from 0 to 100, which higher score indicates better functional scale or worse symptomatic level

Time frame: Change from baseline to week 12

Change in mean daily energy and protein intake at 12 weeks

Higher intake of daily energy and protein indicates improved oral intake

Time frame: Change from baseline to week 12