Comparative Study of Metformin Versus Doxycycline in Moderate to Severe Adult Acne Vulgaris Patients.

Phase 2RecruitingNCT06252194

Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh120 enrolled

Overview

The goal of this clinical trial is to compare the effect of doxycycline and metformin in treatment of acne vulgaris patients. The main question is aimed to answer is whether metformin is more effective than doxycycline in treatment of acne vulgaris patient or not. Patients will be asked to take doxycycline along with tropical treatment in one group and metformin along with tropical treatment in another group. Researcher will compare the clinical improvement in two groups.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

120

Conditions

Acne Vulgaris

Interventions

Metformin and doxycycline

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: Newly diagnosed moderate and severe AV patients diagnosed by a dermatologist \- Exclusion Criteria: * Patients receiving topical retinoids within last two months * Pregnancy and lactation * History of corticosteroids intake * Suffering from malignancy or any cosmetic induced acne

Outcomes

Primary Outcomes

Global Acne Grading System (GAGS) Score

Acne Vulgaris Severity assesment by GAGS score

Time frame: 12 weeks