The Effects of tDCS Combined With rTMS on Post-stroke Cognitive Impairment

The Second Affiliated Hospital of Dalian Medical University60 enrolled

Overview

If there is a comparison group: Researchers will compare \[insert groups\] to see if \[insert effects\] The purpose of the clinical trial is to find a treatment for stroke patients with cognitive impairment, and the main questions it aims to answer are: * \[Search for effective treatments of cognitive impairment after stroke\] * \[Explore brain network features with functional near-infrared spectroscopy\] Participants will receive conventional treatment, tDCS treatment, or rTMS treatment, or tDCS-rTMS treatment. And then compare cognitive function and brain function.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Stroke

Interventions

routine treatment

Eligibility

Sex: ALLMin age: 30 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Meet the clinical diagnostic criteria of the Expert Consensus on the Management of Cognitive Impairment after Stroke in 2021; * 30-80 years old, right-handed, unilateral hemiplegia; * Verbal expression can cooperate with the completion of the evaluation, sustained attention time is longer than 5 minutes; * Simple Mental State Examination Scale (MMSE) score ≤26 points; MoCA scale score \< 26 points; Memory test (RMBT) score less than 21 points; * patients or their family agree to sign the informed consent; * The Ethics Committee approved the trial. Exclusion Criteria: * Memory dysfunction caused by other diseases, such as Alzheimer's disease, lewy body dementia, pituitary tumor surgery, hypothyroidism, etc.; * There are contraindications of rTMS and tDCS for untreated intracranial aneurysms, severe epilepsy, intracranial metal, etc. * Patients with severe visual, cognitive or speech impairment who cannot cooperate with treatment; * The condition is not stable; Or other serious physical diseases.

Outcomes

Primary Outcomes

Concentration of brain's HbO by functional near-infrared spectroscopy

fNIRS

Time frame: 2 weeks

Secondary Outcomes

Score of Mini-Mental State Examination

MMSE

Time frame: 2 weeks

Score of The Frontal Assessment Battery

FAB

Time frame: 2 weeks

Score of Attention assessment by the digit span task

DST

Time frame: 2 weeks

The Effects of tDCS Combined With rTMS on Post-stroke Cognitive Impairment

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts